Path Final block 2 Infectious Diseases
Terms
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- S. aureus Protein A fxn
- binds to Fc segment of Ig = inactivates complement cascade
- S. aureus Coagulase fxn
- coat bacteria with fibrin = inhibits opsonization and phagocytosis
- Most common cause of Osteomyelitis and Endocarditis
- S. aureus
- common cause of UTI in young females
- Staph saprophyticus
- TSST-1
- S. aureus
- Scalded Skin Syndrome
- Exfoliative toxins from S. aureus
- Food poisoning 2-6 hrs. after a family reunion picnic
- S. aureus = ingestion of Enterotoxin, not ingestion of organism
- Carbuncles and Furuncles
- S. aureus
- Impetigo and Erysipelas
- S. pyogenes
- Gram + lancet shaped encapsultated microbe
- Strep pneumo = pneumococcus
- 2 sequela of S. pneumo
-
Meningitis
Inner Ear infection - Leading cause of neonatal pneumonia, meningitis, and sepsis
- Streptococcus agalactiae
- Large, Gram + ROD that forms environmentally stable SPORES
- B. anthracis
- Most common type of Anthrax
- Cutaneous = "malignant pustule"
- Wool-sorter's disease = ?
- Pulmonary anthrax = mediastinal widening
- Mediastinal widening
- Pulmonary Anthrax = good evidence of bio-terrorism
- Unilateral Lymphadenopathy and Fever after a cat scratch
- Bartonella Henselae = Cat Scratch fever
- pseudo-membrane in the posterior pharynx, which can be aspirated and cause death from asphyxiation
- Corynebacterium diphtheriae
-
conjunctivitis
pharyngeal membrane
bull neck
severe Myocarditis - C. diphtheria
- What do you not give to person infected with Diphtheria?
- Vaccine = makes myocarditis worse
-
Encapsulated Gram - cocco-bacillus that causes severe Upper RT infections, epiglottisis, otitis media, and meningitis
*mostly in children - H. influenza
- Grows as satellite colonies next to S. aureus on blood agar
- H. influenza
- Whooping cough
- Bordetella pertussis
- can cause DIC and Water-House Friderichson Syndrome
- N. meningitidis
- cause of meningitis in college dorms and summer camps
- N. meningitidis
- toxin that ADP-ribosylates EF-2 thereby inhibiting protein synthesis
- Diphtheria toxin
- Describe H. influenza vaccine
- Type b capsule conjugated with Diphtheria toxoid protein
- Complememt deficiency (C5-C9) microbe
- N. meningitidis
- cause of Traveler's diarrhea
-
ETEC
-LT = increased cAMP
-ST = increased cGMP - causes child diarrhea in 3rd world countries due to malabsorption by adhering to and deforming intestinal villi
-
EPEC
**P = "preemie" = babies - E. coli clinically indistinguishable from Shigellosis
- EIEC = bloody diarrhea
- ETEC enterotoxin is similar to this toxin
- Cholera toxin
- associated with Hemolytic Uremic Syndrome
- EHEC
- Shiga toxin pathology
- necrosis of epithelium -> A-B toxin -] 28S rRNA
- "Enteric Fever" agent
- Salmonella
- Gall bladder is common reservoir for the enteric pathogen
- Salmonella typhi
- Microbe that has black colonies on Hektoen plates
- Salmonella
- Typhoid Fever
- Salmonella
- Rice-water stools
- Cholera
- Bloody diarrhea related to H. pylori that is transmitted by water, milk, and food
- Campylobacter jejuni
- Friedlander's pneumonia
- Klebsiella
- Encapsulated organism that causes pneumonia and may cavitate resembling TB
- Klebsiella
- Intracellular organism that needs to be treated with Marcolide that causes 5-lobe pneumonia
-
Legionella pneumonia
*treated with Macrolide b/c it's intracellular - grown on Charcoal Yeast Extract plates and stained with Dieterle silver stain
- Legionella
- Found around big buildings in water sources (condensors, AC)
- Legionella
-
Found in standing water
Multidrug resistant
Common in CF patients - P. aeruginosa
- Fruity odor colonies
- P. aeruginosa
-
Ecthyema Gangrenosum - P. aeruginosa vasculitis
- Pseudomembranous Colitis
- C. difficile
- Gas gangrene
- C. perfringens
- C. difficile infection is associated with this antibiotic use
- Clindamycin
- "Undulant Fever" infecting Macrophages/monocytes
- Brucella
- Brucella complications (2)
-
Osteomyelitis
Septic Arthritis -
Non-caseating granuloma
Gram - coccobacilli
eating goat cheese - Brucella
- found among rodents in desert SW and transmitted to humans by fleas
- Yersinia pestis
- Bubonic plague
- Yersinia pestis
- Rabbit Fever transmitted to humans by ticks
- Tularemia
- Lyme Disease agent
- Borrelia Burgdorferi
- Erythema Chronicum Migrans = "bull's eye rash"
- Borrelia burgdorferi
- Borrelia burgdorferi vector
- Ioxodes tick
- Jarisch-Herxheimer rxn
- Borrelia burgdorferi
-
1. Rash
2. Meningo-encephalitis + Myopericarditis
3. Polyarthritis - Borrelia burgdorferi = Lyme Disease
- Histopathologic lesion of Rickettsial infections
- Typhus nodule =infection of endothelial cells
- Where is RMSF most common
- Appalachian mountains
- Petechial rash appearing on palms and soles and moving centripally to trunk
- RMSF
- transmitted by Dermacentor tick
- RMSF
- Weil-Felix serological test may be diagnostic
- RMSF