MedChem III
Terms
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- phentolamine
- competetive non-selective alpha- antagonist
- Phenoxybenzamine
- irreversible non-selective alpha- antagonist
- What drug treats Pheochromocytoma?
- Phentolamine (competitive), Phenoxybenzamine (irreversible)
- Prazosin
-
Selective alpha-1 receptor antagonist
tx- BPH/antihypertensive - Doxazoin
-
Selective alpha-1 receptor antagonist
tx- BPH/antihypertensive - Terazosin
-
Selective alpha-1 receptor antagonist
tx- BPH - Tamsulosin
-
Selective alpha-1a receptor
tx- BPH - Propanolol
-
Non-selective beta 1 & 2 antagonist
tx- arrhythmias (NO asthma), anxiety,hypertension, migraine - Metaprolol
- Selective beta-1 antagonist
- Pindolol
-
Partial Agonists
-give to pts with hyperlipidemia and bradycardia
tx- those who develop bradycardia from propanolol - Who can you NOT give Propranolol to?
- Asthmatics, hyperlipidemics, diabetics
- Labetalol
-
Mixed antagonists
alpha-1, beta-1, beta-2
tx- hypertension - Timolol
-
non-selective beta blocker
tx- glaucoma - adverse effects of beta-blockers?
- hypotension, bradycardia, fatigue, insomnia, sexual dysfunction
- What do aldosterone, renin and ADH have in common?
- all increase blood pressure
- Metyrosine
- Blocks Tyrosine Hydorxylase
- Reserpine
- Blocks storage of catecholamines- crosses BBB
- Cocain/ TCAs
- Block reuptake of catecholamines in synaptic cleft
- Guanethidine/Butilium
- Prevents release of catecholamines from vessicle- VAMPS
- Amphetamine, Ephedrine, Methylphenidate
- stimulate the release of catecholamines
- alpha- methyldopa
- false-transmitters --> drugs act like NT or inhibit action potential
- Where is MAO located?
- Mitochondria
- Where is COMT located?
- cytoplasm- synapse
- How do you measure NE release?
- Vanillylmandelic Acid
- What are the three catecholamines?
- Catechol, NE, Phenylethylamine