Pharmacology Reproductive and Sexual Dysfunction Machini NSU Nova PA Naples
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- What are contraindications for Levonorgestrel?
- Contraindicated in active thrombophlebitis or thromboembolic disease, undiagnosed abnormal genital bleeding, known or suspected pregnancy, hepatic disease , benign or malignant liver tumors, known or suspected breast cancer.
- Oral contraceptives are contraindicated in patients with
- in known or suspected neoplasms do not use
- Adverse effects or oral contraceptions
- breast tenderness, weight gain, dizziness, and headaches
- Adverse effects of Tamoxifen
- priritus vulvae and dermatitis, pain or inflammation at the tumor site, cause uterine cancer, macular edema and retinopathy, nausea and vomiting, hot flashes
- Adverse side effectss of Raloxifene
- increased risk of deep-vein thrombosis (DVT), pulmonary embolism, retinal-vein thrombosis
- A benefit of Toremifene over Tamoxifen is that it does not increase the risk of ______ cancer.
- Endometrial
- This drug is a nonsteroidal partial antagoist that induces ovulation presumaby by blocking hypothalamic estrogen receptors.
- Clomiphene's MOA
- Perogonal and Metodin are associated with what syndrome?
- Ovarian hyperstimulation syndrome
-
Mifepriston is an ______
what class? - antiprogestin
- Give example of estrogens. Generic names
- Diethylstilbestrol, estradiol, estriol,estrone, ethinyl estradiol, Mestranol
- Young athletes who abuse andorgens ahould be made aware of the side effects of these drugs.... which are
- Increased muscle mass, overly aggressive behavior, decreased spermatogenesis, stunted growth
- A 70 year old woman is being treated with raloxifene for osteoporosis. There is an increased risk of her developing...
- vein thrombosis
- A 23 year old woman has failed to become pregnant after 2 years of unprotected intercourse. Which would be effective in treating infertility due to anovulatory cycles?
- Clomiphene
- Treatments for osteoporosis include...
- Dehydroepiandrosterone (DHEA), estradiol, tamoxifen, mestranol
- Estrogen replacement therapy in menopausal women
- is most effective if institured at the first signs of menopause.
- A 66 year old man complained of decreased libido and difficulty maintaining an erection. He is currently taking tamsulosin for benign prostatic hyperplasia. He is concerned about the use of drugs to restore sexual function, particularly about the need to
- Tadalafil is indicated because it can be used comcomitantly with tamsulosin.
- Which causes osteomalacia and bone pain when administered chronically?
- Etidronate
- 58 yr old male has been effectively treated for Paget disease for approximately six months. He is now beginning to experience renewed bone pain and radiologic evidence of advancing disease. Which drug is most likely to have resulted in this failure of th
- Calcitonin
- Give examples of selective estrogen modulators?
- Clomiphene, Raloxifene, Tamoxifen, and Toremifene
- Hydroxyprogesterone, Medroxyprogeterone, Norehindrone, and Norgestrel are what class of drugs
- Progestins
- Bicalutamide, Cyproterone acetate, Finasteride, Flutamide, Nilutamide are what class of drugs
- Antiandrogens
- Danazol, Fluoxymesterone, Nandralone, Stanozolol, and Testosterone cypionate are what class of drugs
- Androgens
- What is the MOA of Progestins?
- Increase in hepatic glycogen, decrease in Na reabsorption in the kidney due to competition with aldosterone at the mineralcorticoid receptor, increase in body temp, decrease in plasma amino acids, increase in excreation of urinary nitrogen
- PMS, dysmenorrhea, and Dysfunctional uterine bleeding you can treat with what drug class?
- Progestins
- Hypoventilation, endometriosis, supression of postpartum lactation, and carcinoma use what drug class?
- Progestin
- Increased ratioof LDL to HDl is an adverse effect of what drug class?
- Progestin
- This drug works by inhibiting ovulation during the follicular phase by blocking hypothlamic-pituitary progesterone receptors, which suppresses midcycle gonadotropin release.
- Mifepristone MOA
- Metastatic prostate cancer can be treated with ____ and ____
- bicalutamide and nilutamide
- Side effects of alpha 1 antagonists like terazosin, doxazosin, tamsulosin, and alfuzosin include
- orthostatic hypotensin and dizziness
- Finasteride is used in the treatment of benign prostatic hypertrophy. It takes how long to work?
- 6-12 months to improve symptoms