Leukemia/Lymphoma
Terms
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- What does staining with MPO indicate?
- Granulocytes
- What does staining with NSE indicate?
- Monocytes
- What does staining with PAS indicate?
- Erythrocytes and lymphocytes
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Leukemia:
t(15;17) -
Promyelocytic
PML-RAR - treat with ATRA - Leukemia t(8;21)
- Myeloblastic w/maturation
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Leukemia:
inv(16) -
Myelomonocytic
Also gum involvement - Markers for B cell ALL
- CD19, CD20, CD10 (CALLA), HLADR-
- Markers for T cell ALL
-
CD2, CD3, CD7
(CD2 is also seen in APML) - What translocations are commonly seen in B-ALL?
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t(8;14)
t(1;19)
t(9;22) - worse prognosis
t(8;22)
t(2;8)
t(4;11) - bad - also biphenotypic AML
t(17;19) - What translocations are commonly seen in T-ALL?
- t(11;14), t(1;14), t(10;14)
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Lymphoma:
Trisomy 12
Del 13q14
Del 11q22-23 - SLL/CLL
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Lymphoma:
CD19, 20, 5, 23+ - SLL/CLL
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Lymphoma
t(11;14) - Mantle Cell Lymphoma (worst prognosis)
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Lymphoma
CD23- - MCL
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Lymphoma
t(14;18) - Follicular Lymphoma
- Back to back follicular growth, no white spaces, centroblasts and centrocytes
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Follicular Lymphoma
t(14;18) -
Lymphoma
t(11;18), Trisomy 3 -
Marginal Zone Lymphoma (MALToma)
Does not respond to abx when there is this abnormality) -
Lymphoma
t(8;14) -
Burkitt's
Starry sky appearance
Associated with EBV, jaw lesion -
Lymphoma:
Loss of CD2, 3, 5, 7 - Peripheral T cell lymphoma
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Lymphoma:
t(2;5) -
Anaplastic Large Cell Lymphoma
Stains for ALK protein