derm review
Terms
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________: a circumscribed change in skin color without elevation or depression.
________: a solid elevated lesion usually 0.5 cm or less in diameter.
________: a raised lesion that has a greater area as compared to its elevation above the ski -
Macule
Papule
Plaque
Wheal (hive)
Nodule -
________: a circumscribed elevated lesion which contains free fluid. Vesicles are 0.5 cm or less in diameter
_______: a circumscribed elevated lesion which contains pus. An abscess is usually in the dermis or subcutis.
________: a non-blanchi -
Vesicle
Pustule
Purpura
Cyst -
Albinism
-People with albinism have little or no pigment in their _________(3).
-They have inherited genes that do not make the usual amounts of melanin
Autosomal _________
People with albinism always have problems with _______, and -
eyes, skin, or hair
recessive
vision -
Therefore the main test for albinism is simply an ____ exam
________ albinism involves the eyes, hair, and skin.
_________albinism involves primarily the eyes, while skin and hair may appear similar or slightly lighter than that of other famil -
eye
Oculocutaneous
Ocular
tyrosinase
"P" -
3 > Cafe au lait spots are asso w/ __________ and rarely ___________
_________ is a type of birthmark that can be confused as a bruise from abuse -
neurofibromatosis
McCune-Albright syndrom
Mongolian spots -
ABCDE’s of moles/melanoma
________- If you draw a line through this mole, the two halves should match. If it is asymmetrical, this is a warning sign for melanoma
______ – benign nevi should have smooth rounded borders. The borders of -
Asymmetry
Border
Color
Diameter
Evolving -
______
a lesion with a centrally placed nevus surrounded by a white halo of depigmented skin.
It is most commonly seen in adolescence, but can be observed at any age.
Over a period of months to years, the halo nevus gradually involutes a - Halo Nevi
-
Staging of Melanoma:
Stage __ - found only in the epidermis (in situ)
Stage __ - less than 1 mm thick, no ulceration, confined to epidermis & upper dermis
Stage __ - either less than 1 mm thick w/ ulceration OR 1-2 mm thick w/o ulcerat -
0
1A
1B
2A
2B
2C -
Staging of Melanoma:
Stage __ - (mets) tumor may be any thickness w/ or w/o ulceration AND has spread to 1 more lymph nodes OR spread to lymph system but no nodes OR spread to matted nodes OR satellite tumors
Stage __ - tumor may be any thickn -
3
4 -
_________ - has the highest cure rate for basal cell and squamous cell carcinomas and is the treatment of choice for locally recurrent skin cancers, offering cure rates of 95 to 97 percent
Thin layers of tissue are systematically excised and examine - Mohs micrographic surgery
-
The pathogenesis of acne vulgaris is multifactorial
Four key factors:
follicular epidermal ___________ with subsequent plugging of the follicle
excess _____
the presence and activity of ___________
_________ -
hyperproliferation
sebum
Propionibacterium acnes
inflammation -
Acne Treatment: oral retinoids
Reducing the secretion of oils from the glands.
This is done by a daily oral intake of ________ derivatives like isotretinoin (marketed as ______,_______) over a period of 4-6 months.
SE:
dry sk -
vitamin A
Accutane, Sotret
nosebleeds
liver enzymes & TGLs
birth defects -
___________ is an uncommon and unusually severe form of acne characterized by burrowing and interconnecting ________ and irregular scars (both keloidal and atrophic), often producing pronounced disfigurement
The comedones often occur in a group of 2 -
Acne conglobata (AC)
abscesses -
___________, also known as acne maligna, was originally described as acute febrile ulcerative acne conglobata (AC)
The primary features of this disease include sudden onset, severe and often ulcerating acne, fever, polyarthritis, and failure to resp -
Acne fulminans (AF)
antibacterial -
__________ refers to the occurrence of keloidlike papules and plaques on the occipital scalp and the posterior part of the neck, almost exclusively in African American men
Initially, patients usually develop a chronic folliculitis and perifolliculit -
Acne keloidalis nuchae (AKN)
occipital -
_____________ is a skin condition in which a person develops small, yellowish growths, usually on the face
A variant of this condition, known as _______ condition causes tiny yellow dots in groups and sometimes in sheets on the lips, inside the mout -
Sebaceous hyperplasia
Fordyce’s -
_______ is an inflammatory skin condition that causes redness of the face
Its characteristics — small, red, pus-filled bumps or pustules — make rosacea often mistaken for _____
In fact, rosacea has been called adult acne or acne rosacea -
Rosacea
acne -
Rosacea Signs and Symptoms:
Red areas on the face
Small, red bumps or pustules on the nose, cheeks, forehead and chin (not the same as whiteheads or blackheads)
Red, bulbous nose (________) – more common in men
Visible small blood -
rhinophyma
ocular rosacea
flush or blush -
Phases of Rosacea:
________ - Rosacea may begin as a simple tendency to flush or blush easily, then progress to a persistent redness in the central portion of the face, particularly the nose. This redness results from the dilation of blood vessels c -
Pre-rosacea
Vascular rosacea
Inflammatory rosacea -
Vitiligo
Aka _________
a chronic skin condition that causes loss of pigment, resulting in irregular pale patches of skin.
The precise etiology of the disease is complex and not fully understood.
___________ therapies to remove the w -
leukoderma
Repigmentation
chemical depigmentation -
⬢ Stratum corneum
⬢ Stratum lucidum
⬢ Stratum granulosum
⬢ Stratum spinosum or mucosum
⬢ Stratum germinativum (also called "stratum basale")
Mneumonic: __________ - "Before sex, get latex condoms" (from deep to superficial)
- ____________consists of small, harmless growths caused by a skin virus. They resemble pimples with a waxy, pinkish look and a small central pit. ;contagious and are spread by direct physical contact. most often in children. When found in adults the direc
- Molluscum contagiosum
-
__________
-many different types
-benign growth that consists of small blood vessels. These tumors can be located anywhere on the body.
-cause is not known. - Angiomas
- __________angiomas and are due to aging and do not have any known significance. ___________angiomas are more common in childhood and during pregnancy, and a few can appear on anyone. When present in large numbers, the may warn of ______damage.
-
Cherry
Spider
liver -
Atrophic hyperpigmented macules on the shins, so-called _________, has been termed the most common cutaneous finding in diabetes
It is usually noted as irregularly round or oval, circumscribed, shallow lesions vary in number from few to many, which -
diabetic dermopathy
asymptomatic -
Diabetic Foot Ulcers:
__: at risk foot with no ulceration
__: superficial ulceration with no infection
__: deep ulceration exposing tendons and joints
__: extensive ulceration or abscesses -
0
1
2
3 -
_________ is a rare fibromucinous connective tissue disorder of unknown cause
characterized by thickened and nonpitting induration of the skin occurring primarily on the _______ -
Scleredema
upper back -
___________: velvety, light-brown-to-black, markings usually on the neck, under the arms or in the groin
most often associated with being _________ -
Acanthosis nigricans
overweight -
Bacterial Endocarditis: Cutaneous manifestations
_______ (on the upper trunk, conjunctivae, mucous membranes, and distal extremities),
painful erythematous subcutaneous nodules on the tips of digits (_______)
nontender hemorrhagic macules -
petechiae
Osler's nodes
Janeway lesions
splinter hemorrhages -
__________ is an illness that involves the skin, mouth, and lymph nodes, and typically affects children who are under the age of 5
causes inflammation in the walls of small and medium-size arteries throughout the body, including the coronary arterie - Kawasaki Disease
-
Phases of Kawasaki Disease:
___ phase - begins with a fever, which often is higher than 104 F (39 C), spikes and remits, and lasts one to two weeks
___ phase - Peeling of the skin on the hands and feet, often in large sheets
J -
1st
2nd
3rd -
____________ is the leading cause of bacterial meningitis and sepsis in children and young adults in the United States
It is spread easily via respiratory secreations
caused by the gram-negative diplococcus _________
The incidence of the d -
Meningococcemia
Neisseria meningitidis -
Meningococcemia S/S:
________ symptoms such as fever, nausea, vomiting, myalgias, and headache
Subsequent development of ________ in these patients is indicated by nuchal rigidity and altered mental status with stupor and obtundation
_____ -
nonspecific
meningitis
petechial -
Syphilis Stages:
______ - chancre or indurated ulcer, which may be insignificant, on the penis, vulva, lip or anus following 18-21 days after exposure
______ - florid symmetrical coppery erythematous macular exanthem that almost always involves -
Primary
Secondary
Latent - _________ minor is a cutaneous eruption which may initially resemble urticaria. The lesions are red, raised, well demarcated plaques which will persist for several days to weeks. The plaques often develop a dusky center producing the classic `_______` le
-
Erythema multiforme
target
sulfa -
When erythema multiforme is severe, extensive, and accompanied by mucosal inflammation and sloughing in a toxic appearing patient with a high fever, a diagnosis of __________ (erythema multiforme major) is made.
pts should be treated in the _______ -
Stevens-Johnson syndrome
burn unit -
________ may be considered an extreme form of Stevens- Johnson characterized by the acute onset of a diffuse erythroderma (usually within 48 hours of starting a drug) with the subsequent development of vesicles that coalesce to form large bullae
The -
Toxic epidermal necrolysis (TEN)
sheets -
A ________ drug reaction (seen with sulfonamides, tetracyclines, and psoralens) involves absorption of ultraviolet radiation and the release of energy causing damage to epidermal cells
An exaggerated sunburn but almost any morphology can occur inclu - phototoxic
- A _________ drug reaction (seen with griseofulvin, thiazides, and chlorpromazine) occurs when ultraviolet energy causes the drug hapten to bind to native protein on epidermal cells, thereby creating a complete antigen that sensitizes nearby lymphocytes.
- photoallergic
- Anaphylaxis Treatment - Administer __________ into a different extremity immediately (the _____ muscle is preferable)
-
IM epinephrine
thigh -
______ is a form of dermatitis, or inflammation of the upper layers of the skin
broadly applied to a range of persistent or recurring skin rashes characterized by redness, skin edema, itching and dryness, with possible crusting, flaking, blistering, -
Eczema
clinically -
______ eczema (aka infantile e., flexural e., atopic dermatitis) is thought to be hereditary, and often runs in families whose members also have hay fever and asthma.
Itchy rash is particularly noticeable on face and scalp, neck, inside of elbows, - Atopic
-
________ dermatitis is of two types: allergic (resulting from a delayed reaction to some allergen, such as poison ivy or nickel), and irritant (resulting from direct reaction to, say, a solvent).
About three quarters of cases of contact eczema are -
Contact
irritant -
______ eczema (aka asteatotic e., e. craquele or craquelatum, winter itch, pruritus hiemalis) is dry skin that becomes so serious it turns into eczema.
It worsens in dry winter weather, and limbs and trunk are most often affected.
The itchy, - Xerotic
-
________ dermatitis (aka cradle cap in infants, dandruff) causes dry or greasy scaling of the scalp and eyebrows.
Scaly pimples and red patches sometimes appear in various adjacent places.
In newborns it causes a thick, yellow crusty scalp ra -
Seborrheic
biotin -
-common skin disease.
-rash that can last from several weeks to several months.
-spring and the fall,
-adolescents and young adults.
-distinctive pattern. In 3/4 of the cases, a single, isolated oval scaly patch (the "_______ -
Pityriasis Rosea
herald patch
ringworm - _________ is a common condition of the beard area occurring in up to 60% African American men and other people with curly hair. The problem results when highly curved hairs grow back into the skin causing inflammation and a foreign body reaction. Over ti
-
Pseudofolliculitis Barbae
Electrolysis -
________ -flaking skin, or reddish patches.
-usually oily,itchy on the face, may cause embarrassment.
- not contagious.
-Scales form on reddened skin.
In adults affects the scalp, eyebrows, ear canals, sides of the nose, and -
Seborrheic dermatitis
dandruff -
Seborrheic dermatitis
treatment
- shampoos containing _______(Head and shoulders, ZNP bar), _______(Selsun blue and prescription strength Selsun) or __________(Nizoral AD and prescription strength Nizoral).
Other shampoo ingredient -
zinc pyrithione
selenium sulfide
ketoconazole
cortisone -
__________
Your skin needs moisture to stay smooth and supple
-difficult in winter.
Simple daily routines actually remove moisture from the skin.
-Modifying your bathing routine will help preserve moisture.
Generally, _______- -
Dry Skin (xerosis)
water -
or clogging of their apocrine glands. It causes chronic scarring and pus formation of the underarms (axilla) and groin/inner thigh areas
-Bacterial infection produces the pain and odor
-worse under stress.
- not by poor hygiene. - Hidradenitis Suppurativa
-
Hidradenitis Suppurativa
--________antibiotics (minocycline, tetracycline, erythromycin, Augmentin, others)
-________antibiotics (clindamycin or erythromycin).
-Intralesional injections
-. Anti-inflammatory pills
-birth contro -
oral
topical -
_________-episodes lasting months to years.
-shiny, flat-topped bumps that often have an angular shape. These bumps have a reddish-purplish color with a shiny cast due to a very fine scale.
-anywhere on the skin, but often favors the inside o - Lichen planus
-
_______most commonly affects the inside of the cheeks, gums and tongue.
-lasts longer than skin type
-patches of fine white lines and dots.
-painful sores and ulcers in the mouth.
-biopsy
-increased risk of oral cancer - Lichen planus of the mouth
-
Nail changes 10 percent of lichen planus cases
-damage to the nail ______, or nail ______.
- few fingernails or toenails
-longitudinal riding and grooving, splitting, nail thinning and nail loss. In severe cases, the nail may be temporar -
matrix
root -
______are benign lesions that occur on the sun-exposed areas of the body.
- backs of hands and face
-increase with age
- 0.2- 2 cm.
-flat discrete borders, dark ,irregular
- biopsy to rule out cancer.
-treatment is not ne - Lentigines, or liver spots
-
-form of 'panniculitis' or inflammation of subcutaneous fat tissue.
-painful, especially if pressed upon.
-looks like painful bruises on both shins.
-bumps on knees, elbows, forearms and thighs.
-feel ill, like "flu". - Erythema Nodosum
-
________ is an immune-mediated disease which affects the skin and joints.
It commonly causes red scaly patches to appear on the skin. (plaques)
Plaques are areas of excessive skin cell production and inflammation. Skin rapidly accumulates at - Psoriasis
-
_______ psoriasis (psoriasis vulgaris) is the most common form of psoriasis
_______ psoriasis (inverse psoriasis) appears as smooth inflamed patches of skin
________ psoriasis is characterized by numerous small oval (teardrop-shaped -
Plaque
Flexural
Guttate
Pustular -
______ psoriasis produces a variety of changes in the appearance of finger and toe nails
________ arthritis involves joint and connective tissue inflammation
_________ psoriasis involves the widespread inflammation and exfoliation o -
Nail
Psoriatic
Erythrodermic -
For psoriasis the therapeutic property of sunlight is due to the wavelengths classified as ___________
________ and ultraviolet A phototherapy (PUVA) combines the oral or topical administration of psoralen with exposure to ultraviolet A (UVA) light< -
ultraviolet (UV) light
Psoralen
skin cancer - SLE characteristic feature is a rash sparing the nasolabial folds - _________
- malar rash
-
_____________ is connective-tissue disease that is characterized by inflammation of the muscles and the skin
Up to 50% of the cases may be a paraneoplastic phenomenon, indicating the presence of _______
The _______ rash consists of a violaceous -
Dermatomyositis
cancer
heliotrope - __________ is a condition that causes some areas of your body — such as your fingers, toes, tip of your nose and your ears — to feel numb and cool in response to cold temperatures or stress. It's a disorder of the blood vessels that supply blood to y
-
Raynaud's disease
nuisance -
__________ - a rare, progressive disease that leads to hardening and tightening of the skin and connective tissues
starts with a few _______ of skin on the hands or face that begin getting thicker and harder -
Scleroderma
dry patches -
Sarcoidosis is a multi system disorder characterized in affected organs by a type of inflammation called ________
presents without symptoms but with an abnormal _________
disease usually regresses spontaneously within _____ of initial presentat -
granulomas
chest radiograph
two years -
ITP, also known as immune thrombocytopenic purpura, is classified as an autoimmune disease - _________ are the target
children with ITP have a very low platelet count - causes sudden bleeding
The usual symptoms are ________ and the tiny red dot -
platelets
bruises
Nosebleeds
menstrual -
_______ disease (erythema infectiosum)-- a common childhood infection causing a _______ appearance and a rash
caused by ___________
It most commonly affects young children and often occurs in several members of the family or school class -
Fifth
slapped cheek
Parvovirus B19 - – where individuals persistantly pull out hairs resulting is an exam revealing short broken hairs in patches . This may be a manifestation of OCD. Treatment is behavioral therapy
- Trichotillomania
-
________, an autoimmune disease, presents as an anagen effluvium. Autoimmune inflammation around the hair follicle aborts hair growth.
Changes in chemical or physical structure of the hair shafts result in hair shaft abnormalities (trichodystrophie - Alopecia areata
-
Treatment: Alopecia Areata
For mild to moderate patchy disease, topical ________are the preferred treatment.
For more extensive or recalcitrant disease, _________ suspension (Kenalog)
topical ________(Rogaine), anthralin (Dritho-Scalp, M -
corticosteroids
triamcinolone acetonide
minoxidil -
_________is an inflammation of the proximal and lateral nail folds characterized by erythema, edema, and pain.
Purulent drainage with compression behind the cuticle may also occur.
-Trauma is often the initial event with secondary infection w -
acute paronychia
anti-staphy -
__________
- longitudinal striations or ridging of the nails.
- simply reflect advanced age
-usually persistent - Oncychorrhexis
-
________ is a superficial infection of the hair follicles characterized by erythematous, follicular-based papules and pustules
________ are deeper infections of the hair follicle characterized by inflammatory
__________ are larger -
Folliculitis
Furuncles
Carbuncles -
Topical treatment with ________ 1% or ________ 2%, with an antibacterial wash or soap, is adequate for most patients with folliculitis
Systemic _________ antibiotics are usually necessary for furuncles and carbuncles, especially when celluliti -
clindamycin or erythromycin
antistaphylococcal
incision and drainage -
Erysipelas is a superficial _________ infection of the skin.
______ is a deeper process that extends to the subcutis
_______ & _______ are the most common pathogens
oral ________ antibiotic is the treatment of choice for cellulitis; -
streptococcal
Cellulitis
S aureus and S pyogenes
antistaphylococcal -
_______ is a collection of pus and infected material in or on the skin
Major complications are spreading of the abscess material to adjacent or remote tissues and extensive regional tissue death (______)
________ & _______ of the abscess is -
skin abscess
gangrene
Incision and drainage
S aureus -
_________ is a rare infection of the subcutaneous tissues and fascia that eventually leads to necrosis
_______ may be the sole pathogen responsible but most patients have a mixed infection
he most common site for infection is the ____, followe -
Necrotizing fasciitis
S pyogenes
legs
crepitus -
Normal Hair cycling
Scalp hair grows in an asynchronous pattern, with approximately 80% of hair follicles in an active growing phase (_______) and 10% to 20% in an involuting(__________) and resting phase(__________)
Telogen hair fibers shed i -
anagen
telogen
catagen