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Micro Exam IV: Innate Immunity (16)

Terms

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specific immune regulators
while the most powerful antiviral interferons belong to alpha and beta groups, the gamma group contains these....
alternative pathway
the activation of a complement in the innate response, when no antibodies are present. Hydrolysis occurs and proteins are introduced that lead to the splitting of C3 into C3a and c3b....this all takes place before the antibody is produced
classical pathway
cascade that involves an antibody
expulsion
after the bacterium is digested, the phagolysosome fuses with the cell membrane and expels indigestible debris
phagolysosome
a phagosome and a lysosome found in a macrophage. the lysosome can include chemicals like lysozyme, lactic acid, nitric oxide, and other oxidants...which are able to kill the bacteria.
complement proteins
nonspecific defense that have receptors that help them bind to the pathogen
phagoctosis
the method that a class of leukocytes use to destroy pathogens.
lymphocyte
30% of WBC, function is for specific immunity
C5a
a product of C3b that attracts phagocytes.
erythema
inflammation causes the capillaries to dilate, blood has an increased permeability (swelling is caused by WBC and serum proteins entering the affected tissue), and causes this. the visibly red color and the warming of the tissue.
cascade
the breaking and binding of complements to each other
plasma
the proteins that make up the noncellular fraction of the blood
C3b
a fragment of a complement component that plays a critical role in the immune response. it catalyzes the splitting of more molecules of C3, to form molecules of itself....but only if invading microbes are present. they form spontaneously and and quickly destroyed. when microbially cells are present, it is stabalized by binding to their surfaces. it interacts with other complement proteins to form C3 convertase, which is a powerful enzyme that rapidly forms many more molecules of itself.
leukocytes
neutrophils, monocytes, basophils, eosinophils, lymphocytes, platelets
chemotactic
describes phagocytes ability to attraction to the site of the battle against the infection because of a concentration gradient.
cell-surface receptors
the proteins that are found on the outer surface. these proteins can bind to molecules on the surface of microbial cells that are not present on host cells.
opsonin
a critical role of C3b as a molecule that can facilitate phagocytosis
eosinophils
2% of WBC, function is for phagocytosis/specific immunity
membrane attack complex
the killing of microbial invaders by making holes in their membranes, cytolysis
fibroblast
a type of cell tissue that produces Beta interferons
inflammation
cytokines are able to coordinate and expand the antipathogen activities of the innate immune system. this is one state which is the fluid accumulates within the affected tissues (causes swelling, redness, and pain)
monocytes
WBC that are found in the blood, can phagocytize, but have no granules. they are not just found in the blood, they are able to enter the tissue, change shape, and become macrophages
neutrophils
they circulate in the blood, but enter any infected tissue, They are the most abundant WBC we have. they live for about two days and only live for a few hours after entering the infected tissue. they are non-specific eaters.
inflammatory mediators
some of the cytokines that cause inflammation.
recognition
the first and critical step of phagocytosis. it is the ability of phagocytes to direct their killing power exclusively toward invading microorganisms, not other host cells,
pus
a yellow fluid mixture of dead microorganisms, leukocytes, microorganisms, and tissue cells
interferons
a small protein that interferes with viral replication. there are many different kinds: alphas, betas, gammas. they are host specific, viral non-specific, but they are induced by only some viruses (not all viruses produce these).
phagocytes
the first effective attack on the invaders
natural killer cells
cells that fight viral and other intracellular infections by killing infected host cells, thereby stopping multiplication of the pathogen. their killing potential is stimulated 20-100 fold after being exposed to certain cytokines (IL-2 and IFN); as they attack the infected cells, these cells also produce cytokines that stimulate macrophages.
opsonins
a coating on bacteria to help engulf it
nonspecific interior defense
inflammation, phagocytosis, complement, and interferon
agranulocytes
MNL-monocyes
Polymorpho nuclear leukocytes
a cell with a nucleus that has many lobes. aka a neutrophil, this cell cleans invading bacteria (a phagocyte)
terminal complement pathway
a immune response of C3b, when C3 enters this pathway, it leads to the formation of the membrane-attack complex
phagosome
a membrane bound vacule within the phagocyte that traps the bacterial cell. It is formed by the psuedopods.
eosinophils
WBC that is found in these 2 situations: some allergies and during parasitic infections
adaptive immune system
incase of an attack on our body, and our innate immune system is overwhelmed, this line of defense is activated. this out our last line of defense. takes days or weeks to activate unless we have previously been exposed to the invader.
mononuclear leukocyte
a cell with a normal nucleus
basophils
0.5% of WBC, function is for phagocytosis/hypersensitivity
granulocytes
found in PMNL (neutrophils, eosinophils, basophils). thegranules may contain lysozyme, protease, DNAase, RNAase, lipase...all of which can break down macromolecules
antibody
a specific defense that covers the pathogen to help phagocytize the bacteria
macrophage
the long-lived, mature form of a monocyte that has left the bloodstream and taken up residence in tissue,
innate immune system
Our defense when our first line of defense is invaded, this is activated and usually eliminates the invaders. aka nonspecific interior defense
complement
a set of microbe-attacking proteins in blood, lymph, and extracellular fluids. the activation of these make up the first response of the innate immune system to invading microorganisms.
respiratory burst
the activation of phsagocytosis by neutrophils. neutrophils start making superoxide
neutrophils
60% of WBC, function is for phagocytosis...it is a major component of our second line of defense. they are the first to arrive at an infection to eat debris and microbes
inflammation
hallmarks include: swelling (edema), redness(erythema), heat, pain
serum proteins
complement proteins. when they are activated they will break apart and combine with otehrs to create new proteins..... protease cascade
monocyte
8% of WBC, function is for phagocytosis/specific immunity
antiviral proteins
enzymes (created and released interferons by other cells that have been infected by a virus) that interfere with viral protein synthesis and thereby stop the spread of infection.
cytokines
as bacteria are degraded, these cellular components are released by the macrophage. they signal other components of the immune sustem to respond to invaders, organizing a coordinated defense. can result in local or systemic effect

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