RE Endocrine Tumors
Terms
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- Pituitary Tumors
-
Prolactin secreting
Non Secreting
GH
ACTH -
women w/amenhorrea, galctorrhea
men w/ED -
prolactin secreting pituitary tumor
(inhib's est & testost)
tx w/DA -
HA, vis field deficit, decreased GH
diabetes insipidus - hypothalamus tumor
- HA, vis field deficit, decreased GH
-
non secreting pituitary tumor
tx w/surgery
dx w/MRI -
kids with gigantism
adults w/acromegally (increased hat & shoe size)
elevated insulin like GF -
GH secreting pit tumor
tx w/somatostatin - treatment of GH secreting tumor
- somatostatin
- hypercortisol sx's w/normal adrenal gland, normal hypothalamus, normal aldosterone
-
ACTH secreting pit tumor
tx w/surgery - Thyroid tumors
-
papillary (most common, best OC)
-ground glass nodules
follicular (responds like pap)
medullary (worst)- calcitonin
Anaplastic
lymphoma - calcitonin is tumor marker for...
-
medullary thyroid
-from cheif cells
common w/MEN2 - thyroid tumor comon w/MEN2
- medullary
-
increased Ca
"Bones, Moans & Psych Overtones" -
hyperparathyroid tumor
(80% are adenoma)
can give DI b/c Ca dmg aquaporins - Pancreatic tumors
-
endocrine= insulinemia, gastrinoma, glucagon secreting, VIP
exocrine= high mortality - Pancreatic endocrine tumors
-
insulinoma
-eat a lot (esp late at nite)
Gastrinoma
-peptic ulcer dz
-tx w/surgery & PPI's
glucagon secreting
-glucose intol
-diarrhea
VIP secreting
-diarrhea - Adrenal adenomas
-
cortisol secreting
-high cort, low ACTH
-sx's like Cushings
Aldosterone secreting
-high ald, low renin
-HTN & HypoK
Pheochromocytoma
-HTN, sweaty, tachy, palp, ortho hypo, doom
-medullary pancreas
MEN1 - HA, HTN, doom
- pheochromocytoma
- MEN 1 tumors affect
-
3 P's
-pancreas (gastrin "Z-E")
-pituitary (vis & GH)
-parathyroid (kidney stones)
kidney stones, - inheritance w/Men tumors
- auto dom
- MEN tumor w/kidney stone & stomach ulcer
-
type I
"wermers"
tumor suppressor gen mutation - MEN w/ongogene activated
-
MEN 2 & 3 (aka 2 b)
"Sipple's"
ret gene - MEN assoc's w/medullary thyroid and/or pheo
- MEN 2 & 3 (aka 2 b)
- MEN associated w/zollinger ellison
- MEN 1
- 3 paraneoplastic syndromes
-
PTH related peptide
-assoc w/squamous cell
ADH secretion
-assoc w/sm cell carcinoma
ACTH secreting
-aggressive