A&P Blood
Terms
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- Physical elements of blood
- both solid and liquid elements, 55% Plasma, PH between 7.35-7.45, Accounts for 8% of body weight. males 5-6L of blood
- Hematocrit
- %of erythrocytes in formed element portion of blood (remaining 45% of blood, without plasma) 45%
- Red Blood Cells, RBC
-
4-6 million
Transport o2 and CO2, Biconcave discs, Lacks mictchondria, 5 million cells per mm3, anucleated - Hemoglobin (Hb)
- Found on RBC's to transport O2, each RBC contains aprox 250mill hemoglobin molecules, each capible of binding 40 molecules of O2. Norm Bl Count 12-18Grams/100mm(ml) blood
- Life of RBC
- 5-7 days for development, Lives for 120 days
- Pernicious
- Lack of Vit B12
- Leukocytes
-
4000-11000 WBC's/mm3
accounts for less than 1% of total blood vol. - Diapedesis
- ability of WBC's to slip thru cell membranes
- Chemotaxis
- WBC's moving to needed site
- Granulocytes
-
Granule containing WBC's:
Neutrophils
Basophils
Eosinophils - Neutrophils
-
Multilobed nucleus
granulocyte
phagocytosis
used in infections - Basophils
-
Rarest WBC, Release HISTAMINE
Granulocyte - Eosinophils
-
ALLERGIC REACTIONS, and PARASITES
Granulocyte - Agranlocytes
-
monocytes- phagocytes
lymphocytes-secrete antibodies - Lymphocytes
- Agranulocytes, tend to live in Lymph tissue, Plays role in immune response
- Monocytes
- Largest of WBC's, indented nucleus, macrophages with huge appetites, fight chronic infection
- Leukocytosis vs Leukopenia
-
cytosis- over 11,000 cells/mm
penia- abnormally low WBC's - Megakaryocytes
- Bizarre Multinucleated cells, pinch off thousands of anucleated platelet peices
- 3 Phases of Hemostatsis
-
-Stoppage of blood
1. Platelet formation of plug
2. Vascular spasms occur
3. Coagulation occurs prothrombin, fibrin etc - Coagulation
- Clotting; Injured tissue releases (TF)tissue factor, PF3 interacts with TF, Vit K and CA, that activates prothrombin to thrombin. Thrombin joins to fibrinogen= Fibrin that traps cells and makes clot
- Agglutination
- Binding of antibodies cause RBC's to clump which leads to the clogging of small blood vessels throughout the body