Hep B
Terms
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- Is an acute hep B illness that bad?
- No, can even be asymptomatic.
- Then why is Hep B virus so bad?
- It persists in 5-10% of immunocompetent people, and causes cirrhosis and hepatocellular carcinoma.
- What causes the pathologic effect of HBV?
- The host's immune response to the persistant virus infected hepatocytes.
- What is HBe Ag?
- A soluble antigen secreted by infected hepatocytes.
- What is HBs Ag?
- The surface antigen of HBV.
- What is a good indication that a person's immune system has cleared the virus?
- Seroconversion of HBeAg to Anti-HBe.
- What are the 3 antigens detected in HBV?
-
Hep B Surface
Hep B Core - its ANTIBODY
Hep B e - Which HBV antigens appear first in infection, and when?
- HBs and HBe Ag; during incubation, 2-8 weeks before any other change occurs.
- How long is HBsAg detectable?
- Through acute phase, clears by convalescence. Usually only 2-6 weeks.
- Which antigen is detectable after HBsAg?
- ANTI-HepBc
- What is a valuable use of Anti-HBc?
-
-It is a lifelong marker of infection with HBV (as IgG)
-Important marker of recent acute infection, esp if HBs and HBe antigens are neg.