Genital Ulcer Diseases
Terms
undefined, object
copy deck
- Three most common GUDs
- Genital Herpes, Syphilis, Chancroid
- Chancroid Ulcer Description
- very deep, locally desctructive lesion, painful, pus filled, bleeds easily
- Genital Herpes Ulcer Description
- chronic, recurring, very shallow small clusters of ulcers, begin as vesicles or blisters, become painful
- Syphilis Ulcer Description
- single, relatively painless, firm to touch, mid size
- Bug causing syphilis
- Treponema pallidum
- Presentation of Primary Syphilis
- ulcer, single painless indurated with clear base (no blister/pus), hard sores
- Presentation of Secondary Syphilis
- wks-mos after primary infxn, fever, headache, muscle/joint pain, loss of appetite, skin rash (variable, can involve palms/soles), adenopathy, hepatitis, nephritis, aseptic meningitis
- Presentation of Tertiary Syphilis
- Benign Late Syphilis (gumma), CV syphilis, Neurosyphilis
- Describe Gumma
- benign late syphilis, gumma nodules, generally benign, can form in organs and be fatal, DTH response to organism
- Describe Cardiovascular Syphilis
- spirochetes infect small vessels in aortic wall --> aneurysms and aortic valve insufficiency
- Describe Neurosyphilis
- General Paresis: direct invasion of cerebrum by t. pallidum; Tabes Dorsalis: infection of small arteries of spinal cord
- Clinical Presentation of neurosyphilitic general paresis
- chronic meningitis, cerebral atrophy, perivascular infiltrates, psychiatric and neurologic condition
- Stages of Latent Syphilis
- Early: first year, most likely transmission; Late: after 1 year
- Describe Early Congenital Syphilis
- snuffles to sanguinous nasal discharge, variable skin rash, condyloma lata, skeletal involvement, hematological abnormalities, CNS involvement
- Describe Late Congenital Syphilis
- skeletal malformations, dental abnormalities, inflammatory lesions (interstitial keratitis), deafness, knee inflammation, neurosyphilis, paroxysmal cold hemoglobinuria
- Hutchinson's Triad
- for late congenital syphilis: Dental Findings, Interstitial Keratitis, Neural Deafness
- Lab Diagnosis of Syphilis
- Darkfield microscopy, nontreponemal tests: ab against cardiolipin antigens released from damaged tissues; Treponemal tests: detect Ab against treponemal antigens (Captia/FTA-abs); MCB: PCR
- Syphilis Treatment
- IM Pen
- Chancroid caused by
- Haemophilus ducreyi
- Clinical Presentation of Chancroid
- Single or multiple relatively deep, tender ulcers, no induration, granular base, irregular border, bleed easily, purulent, development of bubo (abscessed LN)