Immunology Test #1
Terms
undefined, object
copy deck
- The distinction between variolation and vaccination?
- In vaccination a nonviable antigen is injected
- Characteristics of innate immunity
- constitutive, rapid, nonspecific, and lack of memory
- What can the innate immune system not recognize?
- nonmicrobial molecules
- 5 External defenses of the innate immune system?
-
1. intact skin
2. tears
3. in the respiratory tract
4. in the digestive tract
5. normal intestinal flora - 5 Internal defenses of the innate immune system?
-
1. chemical/physio barriers
2. NK cells
3. interferons and cytokines
4. alternative complement pathway
5. detetion of pathogens - What is an example of a PAMP on gram-negative bacteria?
- LPS
- Why do T-cells need 2 signals?
- To distinguish self from non-self
- How do phagocytes degrade ingested material?
- Fusing with a lysosome to form a phagolysosome
- What cells can mediate phagocytosis?
- Monocytes/Macrophages, Dendritic Cells, and Neutrophils
- How do B and T cells interact with antigens?
- noncovalently
- 2 types of memory cells
- Effector and Central
- Cell/mediated immunity provides protection against viruses in what phase?
- intracellular
- Where do antigens and B-cells interact?
- spleen and lymph nodes
- 2 pathways of hematopoietic stem cells and their products?
-
Lymphoid- B and T cells
Myeloid- erthrocytes, megakaryocytes, basophils, eosinophils, neutrophils, monocytes, and DCs - What are the only cells in the body responsible for humoral immunity?
- B cells
- What on B-cells recognizes native antigen?
- mIg
- What do mature B-cells express?
- IgM and IgD
- What is the pathway of immature T-cells in terms of CD4CD8?
- double negative, the double positive, then single positive
- Where are circulating DCs found?
- in the blood and lymph
- Where are Interdigitating DCs found?
- T-cell areas of secondary lymphoid tissue and the thymic medulla
- Where are Interstitial DCs found?
- most organs
- Where are Langerhans cells found?
- in the epidermis and mucous membranes
- What are iccosomes?
- structures on follicular DCs that are covered in antibody-antigen complexes
- NK cells use Antibody-Dependent Cell-Mediated Cytotoxicity to kill what targets?
- Targets coated in IgG antibody
- What type of lymphatics do the bone marrow, spleen and thymus have?
- Only efferent lymphatics
- What do stem cells become when they become metabolically active?
- progenitor cells