FA Immunology 186
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- What cytokines are secreted by Th cells?
- IL-2,4,5,6, gamma-IFN
- What cytokines are secreted by Macrophages?
- IL-1, TNF-alpha, IL6,IL12
- What cytokines are secreted by activated T cells (not specified)?
- IL-3
- What cytokines are secreted by B cells?
- IL-12
- What cytokines are secreted by Th2 (specifically)?
- IL-10
- In general, what are the functions of IL1-5?
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Hot T-Bone stEAk
IL-1: Fever
IL-2: T cells
IL-3: Bone marrow
IL-4: IgE
IL-5: IgA - Stimulates T cells, B cells, neutrophils, fibroblasts, and epithelial cells; an endogenous pyrogen
- IL-1 (macrophages)
- Stimulates growth of Th and Tc cells
- IL-2 (Th)
- Supports the growth and differentiation of bone marrow stem cells (like GM-CSF)
- IL-3 (activated T cells)
- Promotes growth of B cells. Enhances class switching of IgE and IgG
- IL-4 (Th)
- Promotes differentiation of B cells. Enhances class switching of IgA. stimulates production and activation of eosinophils.
- IL-5 (Th)
- Stimulates production of acute-phase reactants and Igs
- IL-6 (Th, Macrophages)
- Major chemotactic factor for neutrophils
- IL-8 (none listed)
- Stimulates Th2 while inhibiting Th1
- IL-10 (Th2)
- Activates NK cells and Th1 cells
- IL-12 (B cells and Macrophages)
- Stimulates macrophages.
- gamma-interferon (Th)
-
Inc IL-2 receptor synthesis by Th cells
Inc B cell proliferation
Attracts and activates PMNs
stimulates dendritic cell migration to LN - TNF-alpha (Macrophages)