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Semester II Physiology GFR and RPF


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Amount Excreted = ___________
Amount filtered + amount secreted - amount reabsorbed
GFR is determined by the pressure difference btwn the _____ and ____, as well as by their physical characteristics.
cappilary and bowmans capsule
NFP= ______________
(Glomerular capillary hydrostatic pressure + Bowmans oncotic pressure) - (Bowmans hydrostatic pressure + Glomerular oncotic pressure)
The filtration coefficient (Kf) is a constant describing the _____ and ____ of the glomerular cappilary.
hydraulic permeability, surface area
GFR= ____ x _____, and its normal value is ____.
NFP, Kf, 125mL/min
Physiologically GFR is controlled through ____ and ____.
Kf, Pgc
Kf and Pgc are controlled through _____ and _____, respectively.
mesangial cell contraction, afferent and efferent arteriolar resistance.
The magnitude of ____ decreases along the length of a glomerular cappilary because ______ pressure increases.
GFR, oncotic
Increased RPF causes an increase in ____, because _____ pressure is reduced.
GFR, oncotic
Afferent vasocontriction causes ____ in GFR and _____ in RPF.
decreases, decrease
Afferent vasodilation causes ____ if GFR and ____ in RPF.
increased, increase
Efferent vasocontriction causes ____ in GFR and ____ in RPF.
increase, decrease
Efferent vasodilation caues ____ in GFR and ____ in RPF.
decrease, increase
Peritubular cappilary pressure is ____ due to resistance of efferent arteriole.
Peritubular oncotic pressure is ____ due to _____.
high, protein free filtrationg into bowmans capsule
Peritubular net filtration pressure favors ____ of water.
Macula densa senese tubular fluid change and initiates changes in renal ____ arteriole resistance.
The macual densa is located on the wall of the ___.
thick ascending limb of loop oh henle
The fluid in the thick ascending limb of the loop of henle is ___.
An increase in GFR due to increase in RPF causes ___ Na and Cl reabsorbtion, and ____ salt content bathing the macula densa.
less, more
Sodium uptake by the macula densa is via a _____, depolarizing the cells and causing the uptake of _____.
Na-H antiport, Ca ions
Ca ion uptake by macula densa causes release of ___ from the basolateral surface.
ATP or adenosine causes ____ of ____ cells and ____ arterioles.
contraction, messangial, afferent
Contraction of mesangial cells decreses _____.
Kf (decreases area for filtration)
Increased sympathetic stimulation ____ GFR and RPF by effecting on ____ receptors.
decreases, alpha-1 (G alpha q- phospholipase IP3 cascade)
Increased sympathetic nerve activity stimulates ___ release and the subsequent formation of the vasocontrictor ______.
renin, angiotensin II
Angiotensin acts on ____ cells reducing ____.
mesangial cells (higher [C] affects afferent), Kf (GFR and RPF)
____ is produced in the kindeys by vascular smooth muscle cells, mesangial cells, endothelial cells, and tubule epithelial cells.
____ serve a protective function preventing excessive contraction at times of sympathetic nerve stimulation and angiotensin II release.
Low angiotensin levels cause a preferential increase in ____ arteriole resistance.
NSAID inhibit cox1 and cox2 therefore preventing ___ synthesis.
NSAID does not significantly alter GFR and RPF but can cause acute renal failure in patients with _____.
elevated renal vasocontraction
____ and __ are released by the heart and brain in response to increases in central blood volume.
ANP and BNP cause ____ in afferent arterioles, inhibit reabsorption of ___ in collecting ducts, ____ synthesis, and the action of _____.
dilate, Na, renin, angiotensin II

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