hearing test 4 final
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- 140. What is an important and unusual protocol for medical-based professional in consideration of auditory dysfunction?
- Often there is no medically based treatment for many or most causes of hearing loss, more value is based on preventing progression
- 141. What is a gene?
- it is the functional unit of genetics, chemical building blocks
- What is DNA?
- nucleic acid molecule that is in the form of a twisted helix full form deocyribonucleic acid
- How are genes and dna related?
- genes make up dna molecules
- 142. What is the relationship between: gene DNA and proteins?
- genes which make up dna instruct the cells to build proteins
- 143. What is the genetic code?
- the entire string of dna
- 144. Approximately how many human genes are there?
- 35,000
- 145. How many chemical base pairs of dna are there?
- 3 billion
- 146. what is junk dna?
- This is the other 95% of dna that aren’t utilized
- Approximately what percentage of human dna is “junk dna�
- 95%
- Why is the term junk dna misleading or inaccourate?
- Because just cause we don’t know what is does does not make it junk
- 147. What is elsi?
- ethical legal social issues this talks about the implications of using genetics so there is no miss use
- 148. What branch of the Us government is funded for the human genome project?
- Department of energy
- 149. What is a person’s genotype?
- the genetic makeup of an organism “genetic codeâ€
- What is a persons phenotype?
- the physical characteristics of a person the observable characteristics
- 150. What is the total number of human chromosomes?
- 46 total chromosomes
- How many autosomes?
- 22 pairs
- How many sex chromosomes?
- 2
- 151. is it possible to have more or less in the number of chromosomes?
- yes example is down syndrome trisomy 21 (3 number 21 chromosomes)
- 152. What is “locus†as regards a gene?
- it is the specific location of a gene on a chromosome
- 153. Approximately what percentage of congenital deafness is genetic in etiology?
- 80% is autosomal recevieve
- 154. As of 2005, approximately how many genetic types of deafness have been documented?
- 400 known genetic deafness of all congenital defness half are due to genetic factors
- 155. In addition to genes which directly cause deafness, what other kinds of genes are involved in deafness?
- direct genes and susceptibility genes
- 156. What is autosomal dominant inheritance?
- it is a type of single gene inheritance where only one mutant gene for trait to be expressed
- What is the probability of a dominant autosomal transmission?
- all you need is one muntunt copy and this will be expressed type of gene 50% normal -50% abnormal
- 157. What is autosomal recessive inheritance?
- this is a type of dingle gene inheritance where two copies of a mutant gene are needed for trait to be exspressed
- What is the probability of a recessive autosomal transmission?
- a 25% chance
- 158. What are some differences between dominant vs. recessive transmission?
- a dominant gene you only need one but a recessive you need two of the same gene in order to get a transmission
- For example, what are the differences in percentage of incidence for recessive and dominant?
- 50% in a dominant and 25% for recessive
- 159. What is another type of genetically transmitted inheritance pattern?
- matrilinear mother passes to all children
- 160. How is a condition like Down Syndrome different from a single gene defect?
- Error in the number of chromosomes affects the entire body
- 161. What are six general classes of problems that can affect the outer ear?
- Physical, dermatological, inflammatory, blockage, trauma or neoplasm,
- 162. What type of hearing loss is associated with outer ear disorders?
- malformed auricle/ microtia
- 163. What general statements can you make regarding congenital malformation of the pinna (and EAC)?
- Stenotic or atresia
- 164. What is microtia (anotia), and atresia?
- No ear cannal
- 165. What is otitis externa?
- It is a skin inflamed
- what are symptoms of otitis?
- swelling and discharge
- What causes otitis?
- Bacteria, virus, fungus, (bacterial otitis) Treatment for otitis?
- 166. What are other inflammatory conditions affecting the auricle and EAC?
- keloids a response to condition keloid a response to condition kelopd inflammatory response
- 167. What are different causes of blockage in EAC?
- Extrinsic objects (foreign body) or intrinsic objects (cerumen or exostosis)
- 168. When is hearing loss associated with disorders of the outer ear?
- when the ear cannal is compromised when it is blocked
- 169. What are some typical traumatic events that can affect the outer ear?
- Extrinsic blockages lacerations burns
- 170. What are malignancies that affect the outer ear?
- cancer
- 171. Does a disorder in OE or ME always have associated hearing loss?
- no not always
- 172. When is hearing loss associated with disorders of the TM?
- When there is a perforation in it
- What type of hearing loss is associated with middle ear disorders?
- 173. What are typical audiometric findings with a disorder of the middle ear?
- more movement at the tm conductive hearing loss larger space
- 174. What is a problem that affects the tympanic membrane?
- perforation or tympanosclerosis
- 175. What are some causes of TM perforation?
- self inflicted trauma ear disease
- 176. What are some test findings seen in TM perforation?
- tymponomitry gives you a volume reading and if the volume is larger then normal then you are measuring more.. ie all the way to the middle ear
- 177. What is tympanosclerosis?
- (Be able to distinguish it from “otosclerosis†later on). White plaque material on TM after affect of inflammation disease classification does not cause hearing loss
- 178. What are risks/complications associated with TM perforation?
- water precautions, risk of infection in me cavities, risk of cholestreatoma, grown in inner ear
- 179. What are four example disorders that affect the middle ear?
- otosclerosis, consequences of trama, otitis media, cholestreatoma
- 180. Generally, what is the actual cause of hearing loss when there is hearing loss in a middle ear disorder?
- occicular chain is compromised
- 181. What are some genetic differences that affect the middle ear?
- Malformed or absent ossicles, may occur in a syndrome like treacher Collins syndrome
- 182. What is one example genetic syndrome that affects both outer and middle ears?
- apent syndrome
- 183. What is otosclerosis?
- fixation of stapes in oval window due to anomalous “new†bone formation
- What happens to cause stapes fixation?
- a bone grows over the stapes What are remedies?
- 184. What traumatic events can affect the middle ear and cause hearing loss?
- ossivular disarticulation, auto accidents. Q-tipping
- 185. What is Eustachian tube dysfunction (ETD)?
- the Eustachian tube can not open
- 186. What are two classes of ETD?
- extrinsic and intrinsic
- What is an example of each of the two classes of etd?
- extrinsic swollen tonsils or adenoids intrinsic inflammation of the et
- 187. What changes in the ME does ETD lead to?
- retraction of tm and breakdown of cells in lining
- 188. In general, what is otitis media?
- Inflammation of the middle ear
- 189. What are characteristics of acute otitis media?
- infection, isolated incidents.
- 190. What are characteristics of otitis media with effusion?
- presence of fluid no infection after edt
- 191. What is cholesteatoma?
- this is the accumulation of dead or exfoliating skin that adds up
- What causes cholesteatoma?
- marginal tm perforation meningitis
- 192. What are consequences if cholesteatoma is not removed?
- this can erode the chain of ossicles and erode into the brain
- What are consequences even if the cholestreatoma is removed successfully?
- may require a hearing aid mild conductive hearing loss
- 193. What typically causes congenital differences in inner ear structure?
- environmental and genetics
- 194. In considering congenital hearing loss, what percentage is inherited/genetic?
- 50%
- 195. What percentage of inherited hearing loss is syndromic?
- 30%
- what percent of hearing loss is Nonsyndromic?
- 70%
- 196. What is an example of a syndrome with hearing loss?
- Treacher colons ir usher syndrome, or pendred syndrome, or alport syndrome
- What else besides hearing loss is involved?
- Blindness or kidney problems or heart problems⬦.
- 197. In considering nonsyndromic genetic hearing loss, what is the most common genetic mutation?
- It is a gene called gjb2 with locus at dfnb1 on chromosome 13 (13q12)
- What percentage of nonsyndromic hearing loss does gjb2 account for?
- 60%
- 198. What are two routes of transmission that infectious disease can reach an inner ear?
- maternal/transplacental bloodstream
- 199. What is the group of infectious diseases which may cause prenatal hearing loss?
- Toxoplasmosis rubella herpes syphilis
- 200. What else can cause cochlear hearing loss in an infant?
- Prematurity, hypoxia, rh incompatibility
- 201. Which infectious disease is a common cause of postnatal/acquired hearing loss?
- Meningitis
- 202. Although not an infectious disease, what inflammatory “disease†is a commonly diagnosed inner ear problem?
- Cytomegalovirus – are deposited into the audio system at birth but shows signs later 1-2 years
- 203. What are symptoms of taking accutane dilantine or quinine?
- vertigo, unilateral sensorineural hearing loss, tinnitus
- 204. What are the four classes/types of ototoxic drugs?
- Antineoplastic, aminoglucoside, loop diuretics, analgesics and antimalarials
- 205. For which type is there a genetically transmitted susceptibility?
- aminoglycoside anitibiotic
- 206. What are two different and distinct ways an inner ear can be damaged?
- duration of exposure and intensity of acoustic stimulation
- 207. What is the name given to hearing changes due to the aging process?
- presbycusis
- 208. What are some of the audiologic findings in presbycusis?
- mild to moderate high frequency snhl reduced word understanding
- 209. What do current and projected US population statistics tell about presbycusis?
- 21% incidence over 5 years in inicially normal hearing people
- 138. what are the four general things that can cause dysfunction of the auditory system?
- disease, degeneration, difference , damage