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fungal, neoplastic, misc diseases of mice and rats

Terms

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fungal diseases
mice and rats:
trichopyton mentagrophytes
pneumocystis carinii
neoplastic diseases
mice:
mammary tumors
lymphosarcoma
respiratory neoplasms

rats:
mammary fibroadenoma
pituitary chromphone adenoma
miscellaneous dz
rats:
malocclusion
heat exhaustion
urolithiasis
ringtail
rat bite fever

mice:
alopeicia
fight wounds
self mutilation (otitis media, acariasis, chem irritants)
infertility
dystrophic mineralization
ulcerative dermatitis
et of trichophyton mentagrophytes for mice and rats
fungus aka favus
trans of trichophyton mentagrophytes for mice and rats
direct contact
fomites
wide host range
clin signs of trichophyton mentagrophytes for both mice and rats
none
head alopenia and focal crusts
histopath and gross path of trichophyton mentagrophytes
histo - silver stain (mice don't have hair invasion)

gross - clin signs
Dx of trichophyton mentagrophytes
culture
lesions
Tx and ctrol of trichophyton mentagrophytes
tx: none

ctrol: sanitaion / good hygien

zoonotic
et agent of pneumocystic carinii
fungus
affects immunocompromised rodents
trans of pneumocystic carinii
direct contact
clin signs of pneumocystsi carinii
both:
srs
clin signs occur late
gross path of pneumocystis carinii
both:
diffusely red
lungs fail to deflate
histopath of pneumocystic carinii
both:
alveoli
eosinophilic, foamy
degenerate macs and neutr
special stains
silver stain
pas
giemsa
Dx and treatment of pneumocystic carinii
Dx both:
histopath
pcr

ctrol both:
management and sanitaion
transmission of mouse mammary tumors
vertically (placental / milk)
strain dependent
clin signs of mouse mammary tumors
located anywhere sq
gross path of mouse mammary tumors
soft, flexhy, well vascularized
Dx of mouse mammary tumors
location
histopath
et of lymphosarcoma (mouse)
murine leukemia virus (retrovirus)
et of respiratory neoplasms
common in older mice
strain dependent
not virally associated
gross path of respiratory neoplasms (mouse)
firm, cirucumscriped pearl to gray nodules
most common rat tumor
mammary fibroadenoma
presentation of mammary fibroadenoma
(rats)
large sw lump
ulceration
dematitis
well encapsulated / benight

tx with surgery
common tumor in older rats
pituitary chroophobe adenoma
clin signs of pituitary chromophobe adenoma
srs
chromodaccorrhea
head tilt
gross path of pituitary chromophobe adenoma
well circumscribed
dark brown to red
compress adjacent brain
pars distalis
et of malocclusion
rats an dmice:
improbper alignemet of maxillary and mandibular incisorys
clinical signs of heat exhaustion in rats
salivation - wet hair coat
increased water consumption
death
risk factors for chronic progressive glomerulonephropathy in rats
age greater than 1 yr
male
sd strain
high protein diet
Igm deposits
prolactin hormones
clin signs of chronic progressive glomerulocephropathy
proteinurea
wt loss
elevated plasma creatinine
gross path of chronic progressive glomerulonephropathy
pale pitted, irregular, enlarged kidneys
histopath of chronic progressive glomerulonephropathy
basement membrane and glomerular tuft thickening

proteinaceous tubular casts

hyperparathyroidism
et of ringtail
high temp and low humidity
et of rat bite fever
rats - strep moniliformis
mice - spirilium muris

zoonotic

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