M1-C4-L18 --> Autoimmune Diseases
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- Describe Polyclonal B cell Activation.
- Molecular mimicry leads to initiation of B-cells to proliferate and secrete IgM without CD4 T cells
- Polyclonoal B cell activation occurs without what?
- CD4 T cell activation
- Polyclonoal B cell activation secretes what?
- IgM - autoimmune antibodies
- How is Type II Hypersensitivity mediated?
- By complements and Fc receptors
- What is the primary cause of tissue injury in Type II Hypersensitivity?
- Anti-tissue antibodies
- In Goodpasture's Disease, autoantibodies bind to what?
- Basememt membrane of Kidney Glomurali and Alveoli of Lungs.
- Goodpasture's Disease is what type of hypersensitivity?
- Type II
- Grave's Disease is what type of hypersensitivity?
- Type II
- In Grave's Disease, autoantibodies bind to what?
- TSH receptors
- In Grave's disease, what occurs due to the binding of receptors? x2
-
1. Activates adenylate cyclase
2. Overproduction of thyroid hormones - Myasthenia Gravis is an example of what type of hypersensitivity?
- Type II
- In Myasthenia Gravis, autoantibodies bind to what?
- ACh receptors on motor end plates of muscles
- On a molecular basis, what is the damage and from what in Myasthenia Gravis?
- Complement mediated degradation of ACh receptors.
- SLE (Systemic Lupus Erythematosus) is an example of what type of hypersensitivity?
- Type III
- SLE autoantibodies bind to what? x6
-
1. DNA
2. Histones
3. Erythrocytes
4. Leukocytes
5. Platelets
6. Clotting Factors - Describe the initiation of insulinitis of IDDM.
- Infiltration of CD8 T-cells and activation of macrophages initiate it.
- Describe Islet cell damage via insulinitis in IDDM.
- Insulinitis will further release cytokines that will activate CD 4 T-cells. Together, both CD4 and CD8 T cells destroy via DTH mechanism.
- Multiple Sclerosis is an example of what type of hypersensitivity?
- Type IV
- MS is associated with autoreactive T-cells from where?
- Inflammatory regions along the myelin sheath of nerve fibers.
- What is unique about pathogenic T cells in the CNS?
- More restricted usage of T-cell receptor ALPHA and BETA chains.