Gastric Hormones
Terms
undefined, object
copy deck
- Physiologic Action of gastrin
- Stimulates acid secretion and growth of gastric oxyntic gland mucosa
- Site of Release of Gastrin
- Gastric antrum and duodenum
- Stimulus for release of Gastrin
- Peptides, amino acids, distention, vagal stimulation
- Physiologic Action CCK
- Stimulates gallbladder contraction, pancreatic enzyme and bicarbonate secretion, and growth of exocrine pancreas
- Site of release of CCK.
- Duodenum and jejunum
- Stimulus for release of CCK
- Peptides, amino acids, long chain fatty acids, (acid)
- Physiologic action of Secretin
- Stimulates pancreatic bicarbonate secretion, biliary bicarbonate secretion, growth of exocrine pancreas, pepsin secretion; inhibits gastric acid secretion, trophic effects of gastrin
- Site of release of Secretin
- Duodenum
- Stimulus for release of secretin
- Acid (fat)
- Physiologic ACtion of GIP
- Stimulates insulin release; (inhibits gastric acid secretion)
- Site of release of GIP
- Duodenum and jejunum
- Stimulus for releaseo f GIP
- Glucose, amino acids, fatty acids
- Physiologic action of Motilin
- Stimulates gastric and duodenal motility
- Site of release of Motilin
- Duodenum and jejunum
- Pancreatic Polypeptids
- Inhibits pancreatic bicarbonate and enzyme secretion
- Site of release of Pancreatic Polypeptide
- Pancreatic islets of Langerhans
- Stimulus for relese of pancreatic polypeptide
- Protein (fat and glucose)
- Physiologic function of somatostatin
- Inhibits release of most other peptide hormones
- Site of release of somatostatin
- GI tract mucosa, pancreatic islets of Langerhans
- Stimulus for release of somatostatin
- Acid stimulates, vagus inhibits release
- Complication associated with somatostatin
- gallstones
- Physiological function of prostoglandins
- Promote blood flow, increase mucus and bicarbonate secretion from gastric mucosa
- Complication associated with prostaglandins
- NSAID-induced gastritis and ulcer disease
- Physiologic action of histamine
- Stimulates gastric acid secretion
- Site of release of histamine
- Oxyntic gland mucosa
- Physiologic action of VIP
- Relaxes sphincters and gut circular muscle; stimulates intestinal and pancreatic secretion
- Site of release of VIP
- Mucosa and smooth muscle of GI tract
- Stimulus for release of VIP
- Enteric nervous system
- Complications associated with VIP
- Secretory diarrhea
- Physiologic actions of Bombesin
- Stimulates gastrin release
- Site of release of Bombesin
- Enteric nervous system
- Physiological action of Enkephalins
- Stimulate smooth muscle contraction; inhibit intestinal secretion
- Site of release of enkaphalins
- Mucosa and smooth muscle of GI tract
- Stimulus for release of enkapalins
- Enteric nervous system
- Physiologic action of Intrinsic factor
- Binds vitamin B12 to facilitate its absorption
- Site of relase of intrinsic factor
- Parietal cells of the stomach
- Type of secretion associated with intrinsic factor
- Constitutive secretion
- Physiologic action of Mucin
- Lubrication and protection
- Site of release of Mucin
- Goblet cells along entire GI tract mucosa
- Stimulus for relase of Mucin
- GI tract irritation
- Disease's associated with Mucin
- Viscid mucus in cystic fibrosis. Attenuation in some cases of peptic ulcer.
- Physiologic action of Acid
- Prevents infection; initiates digestion
- Site of release of Acid
- Parietal cells of the stomach
- Stimulus for release of Acid
- Gastrin, histamine, acetylcholine, NSAIDs (indirectly)
- Diseases associated with Acid.
- Acid-peptic disease