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Clinical Vignettes: Heme

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5yr old white female complains of fever, marked weakness, pallor, bone pain and bleeding from nose; HPI: increasing fatigability and recurrent infections in last few months; PE: epistaxis, ecchymotic patches on skin, sternal tenderness, slight hepatosple
Acute Lymphocytic Leukemia (ALL)
25yr old white woman presents with high-grade fever, menorrhagia, and weakness; HPI: recurrent infections in recent weeks; PE: pallor, multiple purpuric patches over skin; hepatospenomegaly, gingival hyperplasia, sternal tenderness; LABS: normocytic, nor
Acute Myelogenous Leukemia (AML)
12yr old male presents with high fever, marked pallor and epistaxis, history of recurrent URIs and high grade fever treated with parenteral antibiotics; HPI: marked weakness over past 3 months, lives near industrial unit that handles benzene; PE: pallor
Aplastic Anemia
66yr old white male recently diagnosed with chronic lymphocytic leukemia comes into ER complaining of fatigue and tachycardia; HPI: urine has been progressively turning dark and red over the course of the day; PE: dyspnea, pallor of skin and mucous membr
Autoimmune Hemolytic Anemia
35yr old woman admitted to hospital with left-sided weakness upon awakening; HPI: her first 3 pregnancies were spontaneously aborted and the 4th resulted in unexpected fetal death; PE: mild pallor, left hemiplegia w/ exaggerated deep tendon reflexes, pos
Antiphospholipid Antibody Syndrome
9yr old girl of African descent presents with swelling of left side of face and jaw of 3wks duration; HPI: loosening of upper second left molar 2 wks ago, no pain despite size of tumor; PE: pallor, large, firm, ill-defined mass encompassing entire upper
Burkitt's Lymphoma
65yr old male lost 12 lbs over the past 4 months with episodes of epistaxis and extreme fatigue; PE: generalized nontender lymphadenopathy, pallor, enlargement of spleen and liver; LABS: markedly elevated WBC (124,000), 90% lymphocytes, no lymphoblasts,
Chronic Lymphocytic Leukemia (CLL)
40yr old white male has occasional fatigue and increasing abdominal girth (large spleen); PE: pallor of skin and mucous membranes, pain on palpation over sternum; LABS: markedly elevated WBC count (130,000), immature granulocytes with normal-appearing on
55yr old male presents with swelling, pain, redness of right leg; HPI: he's retired and leads sedentary lifestyle, admits to 70-pack-year smoking history and occasional alcohol intake; PE: fever, tachycardia (106), mild HTN (142/92), normal RR, lower ext
Deep Vein Thrombosis
25yr old white female continues to bleed steadily after a normal, spontaneous vaginal delivery; HPI: after manual exploration of uterus and subsequent procedure, patient begins to bleed profusely from her gums and continues bleeding vaginally; PE: diffus
Disseminated Intravascular Coagulation

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