Dist of circ
Terms
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- 3 components of hemostasis
-
blood vessel wall
platelets
coagulation factors - endothelium antagonize formation of clots by:
-
-negative surface charge (repel plts)
-expression of endogenous anticoagulants (heparin)
-production of substances that are vasodilatory and interfere with plt activation (ADPases) - Constant laminar flow:
- minimizes vascular trauma and dilutes any local accumulation of procoagulats
- Edothelin is a
- vasoconstrictor that temporarily decreases bld flow.
- Primary hemostatic plug forms when
- injury to endothelial extracellular matrix which results in plt adhesion and activation
- The primary hemostatic plug ultimitaly: (falls off or remains attached)
- Which type of hemostatic plug falls off (primary or secondary)
- Tissue factor
- triggers sequential activatoin of a cascade of protein coagulation that eventually forms a thrombin.
- Thrombin converts ____ to ___.
- What converts fibrinogen to fibrin?
- Secondary hemostatic plug is formed by:
- fibrin which polymerizes and incorprates platelets forms the ___ ____ ___.
- What is activated at the same time as clotting?
- Counter-regulartory anticoagulant mechanisms to contain the process to the site of the injury.
- Overactivity of coagulation leads to:
- Thrombosis
- Underactivity of coagulation leads to:
- Uncontrolled hemorrage
- ___ produces NO (nitric oxide)
- Endothelial cells produce ___ an antithrombin which inhibits adhesion of activated platelets.
- ___ produces protacyclin
- Endothelial cells produce ___ an antithrombin which inhibits adhesion of activated platelets.
- ___ produces ADP (degrades a stimulant of platelet aggregation)
- Endothelial cells produce ___ an antithrombin which degrades a stimulant of plt aggregation.
- ___ produces membrane associated heparin-like anticoagulats (cofactors for antithrombin III which inactivates coagulation factors.
- Endothelial cells produce ___ an antithrombin which inactivates coagulation factors
- ___ produces proteins C and S (degrade coagulation factors)
- Endothelial cells produce ___ an antithrombin which are vitamin K dependant factors that degrade coagulation factors.
- ___ produces tissue plasminogen activator (t-PA) that promotes lysis of fibrin - dissolve clots
- Endothelial cells produce ___ an antithrombin which promote lysis of fibrin (dissolve blood clots).
- ___ produces vWF (von Willebrand factor
- Endothelial cells produce ___ a prothrombin which needed for platelets to bind to collagen and other surfaces.
- ___ produces tissue factor
- Endothelial cells produce ___ a prothrombin which activates teh coagulation cascade.
- ___ produces inhibitors of plasminogen activator (PAIs)
- Endothelial cells produce ___ a prothrombin that inhibits the lysis of fibrin.