nutrition in prengna
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Recommended weight gains in pregnancy:
Underweight BMI<19.8 - 28-40
- Normal BMI 19.8-26
- 25-35
- Overweight BMI 26-29
- 15-25
- Obese BMI >29
- >15
- total energy needs are estimated to be ______ for an uncomplicated 40 week pregnancy
- 55,000kcal
- The total iron requirement for an uncomplicated 40 week pregnancy is _______
- 1000mg
- Less than _____ of women have sufficient iron stoores to support the high requirement of pregnancy
- 50%
- Prevalence of iron deficiency is increased among women who:
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1)are members of minority
2)live in poverty
3)have fewer than 12 yrs education
4)have two or more children - Studies have demonstrated a link between iron deficiency anemia early in pregnancy and risk for _______.
- premature birth
- Maternal iron deficiency anemia during pregnancy is also associated with _____.
- low birth weight
- What are the 3 possible mechanisms by which iron deficiency anemia might cause preterm delivery?
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1)chronic hypoxia initiating stress response
2)increased oxidative stress
3)infection due to impaired immune status - High blood levels of hemoglobin and other markers of iron status, such as ferritin, have also been associated with adverse pregnancy outcomes including preterm delivery, low birth-weight, ______ and _____.
- preeclampsia and gestational DM
- The neural tube (precursor of the brain and spinal cord) forms _____ after fertilization of the ovum
- 20-28days
- What are two examples of neural tube defects?
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1)spina bifida
2)anencephaly - It is clear that development of NTDs can be modulated by diet. Currently it is believed that _____ may be important in the development of NTD
- nutrient-gene interaction
- This percentage of women who deliver a baby with a NTD have no prior history of NTD
- 95%
- Orange juice contains how many micrograms of folic acid per cup?
- 109mcg = .109mg
- Women of childbearing age should consume how much folic acid per day?
- 0.4mg
- What other drugs can cause birth defects such as cardiovascular defects, oral clefts, UTI, including NTDs
- trimethoprim, triamterene, carbamazepine, phenytoin, phenobarbital, primodine
- What nutrients are involved in methyl group metabolism?
- folic acid, choline, and methionine
- This nutrient appears to be an important mediator of neural tube closure
- choline and folate
- This nutrient appears to be important later in fetal development as a factor influencing hippocampal development and affecting memory in offsprin
- choline and folate
- Studies have shown that women who consume 4500+mcg of vitamin A per during early pregnancy have a 3.5fold increased risk for delivering a baby a _______
- birth defect
- Nutritional complications of FAS include protein-energy malnutrition )retards brain development), ______, ______, __________
- zinc deficiency, folic acid deficiency, and increased oxidative stress
- What two of the most common congenital abnormalities affecting male births are associated with paternal, not maternal expossure to pesticides or smoling?
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cryptorchidism (pesticides)
hypospadias (smoking)-weak association with brain tumors and lymphoma - This is present in very high concentrations (____) in semen
- vitamin C 400uM
- Nutrients that have been identified as potentially important mediators of male fertility include?
- folic acid, zinc, vitamin C
- What are the four artificial sweeteners approved by FDA?
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1)aspartame
2)saccharin
3)sucralose
4)acesulfame K - Individuals with phenylketonuria should be aware tha phenylalanine will be release from what artifical sweetener?
- aspartame
- What dietary fat substitutes are currently in use in the US?
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1)simplesse
2)dairy-lo
3)litesse
4)olean - What is simpleese
- microparticulated protein
- What is dairy-Lo?
- modified whey protein concentrate
- What is Litesse?
- polydextrose
- What is Olean
- non-caloric fatty acid esters of sucrose (OLESTRA)
- This fat substitue is currently only found in savory snack foods, such as potato chips, corn chips, and crackrs
- Olestra
- How many americans aged 40 and over are blind and in addition how many are visually impaired
- >1 million, 2.4million
- what are the leading causes of vision impairment and blindness in the US?
- diabetic retinopathy, age-related macular degeneration, cataract, glaucoma
- What is the primary cause of incurable blindness in the united states
- Age-related macular degeneration (AMD)
- What are the risk factors for AMD?
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1)age >60
2)female gender
3)FH
4)race (caucasions)
5)smoking
6)high dietary intake of fat and cholesterol - What is the implicated pathology of AMD?
- oxidative damage
- What supplementation may implicated in potentially conferring protection against AMD?
- antioxidants (vitamin E, C, and beta-carotene), zinc, copper, lutein (zeaxanthin-carotenoids that are selectively concentrated in the macula)
- Most, but not all, epidemiologic stuides have reported an inverse associateion of ______ intake/blood levels and incidence of cataract
- vitamin C
- What are lens defenses against cataracts?
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-antioxidants
-enzymes (superoxide dismutase, catalase, and glutathione-glutathione peroxidase system)
-proteases - What is the concentration of Vitamin C in the lens?
- >3mM
- Blood levels of ____ and ____ were decreased 22% in the groups receiving the antioxidant cocktail
- lutein and zeaxanthin
- What were the results of the antioxidant +/- zinc AREDS study?
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1)reduced risk for PROGRESSION to advanced AMD and loss of vision among high-risk participants (pre-existing characteristics of AMD) supplemented w/ either zinc or antioxidants AND zinc
2)little effect on progression in pts with less severe pre-existing conditions
3)no effect on development and/or progresson of lens opacities or visual acuity loss was observed in cataract arm - It is suggested that among the approximately 1.3 million older individuals who develop advanced AMD annually, more than _____ cases could be avoided thorugh appropriate supplementation
- 300,000 cases
- This is presumed to be of primary improtance in protectin gthe brain from oxidant damage
- vitamin E
- This fraction of vitamin E may be more important than other forms of vitamin E for neuroprotection
- tocotrienol