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Pediatric Hematology Oncology: Content Outline

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what shifts the oxygen dissociation curve to the right (increased oxygen release, decreased oxygen affinity)
increased temp
increased 2,3 DPG
increased acid (= decreased pH)
what is the source of ATP and 2,3 DPG
anaerobic gycolysis
how does parvovirus B19 infection suppress erythropoiesis
impairs erythroid precursors
is splenectony curative in pk deficiency
no hemolysis and gallstone production may persist after splenectomy
What is the inheritance of triose phosphate isomerase deficiency
AR
what is the mode of inheritance of phosphoglycerate deficiency? how does this distinguish it from other glycolytic disorders?
x linked
others are AR
What is the basis of homozygous hereditary persistence of hgb F
absence of delta chain synthesis
do maternal anti-lewis antibodies cause hemolytic disease of the newborn?
no
what is a hemotologic complication of recluse spider bites
intravascular hemolysis
what is a hemotologic complication of thermal burns and envenomization
acquired spherocytic anemia
what nutritional deficiency is seen with use of anticonvulsant therapy
folic acid deficiency
what supplement is needed in hemolytic anemia associated with intravacular hemolysis
iron therapy
what morphological finding is associated with CDA type 2
multinucleated erthyroblasts
what gene mutation is associated with the development of secondary leukemia in patients with kostmann syndrome (congenital neutropenia).
gcsf receptor mutation
neutropenia is associated with what nutitional deficiencies
copper
B12
folate
what are alder reilly bodies, what are they associated with?
PMN inclusion bodies
mucopolysaccaroidoses
miscellaneous causes of neonatal thrombocytopenia
occult large vessel or catheter thrombosis
placental vessel hemangiomas or thrombosis
hemolytic disease of the newborn

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