Pediatric Hematology Oncology: Content Outline
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- what shifts the oxygen dissociation curve to the right (increased oxygen release, decreased oxygen affinity)
-
increased temp
increased 2,3 DPG
increased acid (= decreased pH) - what is the source of ATP and 2,3 DPG
- anaerobic gycolysis
- how does parvovirus B19 infection suppress erythropoiesis
- impairs erythroid precursors
- is splenectony curative in pk deficiency
- no hemolysis and gallstone production may persist after splenectomy
- What is the inheritance of triose phosphate isomerase deficiency
- AR
- what is the mode of inheritance of phosphoglycerate deficiency? how does this distinguish it from other glycolytic disorders?
-
x linked
others are AR - What is the basis of homozygous hereditary persistence of hgb F
- absence of delta chain synthesis
- do maternal anti-lewis antibodies cause hemolytic disease of the newborn?
- no
- what is a hemotologic complication of recluse spider bites
- intravascular hemolysis
- what is a hemotologic complication of thermal burns and envenomization
- acquired spherocytic anemia
- what nutritional deficiency is seen with use of anticonvulsant therapy
- folic acid deficiency
- what supplement is needed in hemolytic anemia associated with intravacular hemolysis
- iron therapy
- what morphological finding is associated with CDA type 2
- multinucleated erthyroblasts
- what gene mutation is associated with the development of secondary leukemia in patients with kostmann syndrome (congenital neutropenia).
- gcsf receptor mutation
- neutropenia is associated with what nutitional deficiencies
-
copper
B12
folate - what are alder reilly bodies, what are they associated with?
-
PMN inclusion bodies
mucopolysaccaroidoses - miscellaneous causes of neonatal thrombocytopenia
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occult large vessel or catheter thrombosis
placental vessel hemangiomas or thrombosis
hemolytic disease of the newborn