Goljan High Yield

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Dz associated w/ anti-acetylcholine receptor?: myasthemia gravis
Dz assoc. w/ anti-centromere Ab?: CREST Sx 60% and PSS 10%
Dz assoc. w/ anti-gliadin Ab?: Celiac Dz (95%)
Dz assoc. w/ anti-glomerular basement membrane?: Goodpasture Sx (90%)
Against what Ab is anti-GBM directed to?: Collagen Type IV
What Dz is assoc. w/ anti-islet cel Abs?: Type I DM
What Dz is assoc. w/ anti-microsomal Abs?: Hashimotos (97%)
autoimmune hepatitis (70%)
Dz. assoc. w/ anti-mitochondrial Abs?: primary biliary cirrhosis (90-100%)
Dz. assoc w/ C-ANCA?: Wegner's Granulnomatosis
Dz. assoc. w/ P-ANCA?: Polyarteritis Nodosa (PAN)
and Hep B associated to PAN
Dz. assoc. w/ anti-parietal cell Abs?: Pernicious Anemia
Dz. assoc. w/ intrinsic factor Abs?: Pernicous Anemia Type I (Ab to B12 prevent binding to IF)
Type II (Ab to IF or complex)
Dz. assoc. w/ anti-smooth muscle Abs?: Autoimmune Hepatitis (70%)
Dz. assoc. w/ anti-thyroglobulin Ab?: Hashimoto (85%)
Grave's (30%)
What Dz is associated w/ myasthemia gravis?: thymoma (60%)
HLA relationship of hemochromatosis?: A3
HLA relationship of Myasthemia Gravis?: B8
HLA relationship of Celiac Dz?: B8 and DR3
HLA relationship of Ankylosing Spondylitis?: B27
HLA relationship of Multiple Sclerosis?: DR2
HLA relationship of Type I DM?: DR3 and DR4
HLA relationship of Rheumatoid Arthritis?: DR4
What is the MCC of Autoimmune Hemolytic Anemia?: Warm IgG Lupus
2nd MCC of Hemolytic Anemia?: Drug Induced Hemolytic Anemia
What two drugs used for HT for pregnancy?: Hydralazine, Methyl-Dopa
Hydralazine causes?: Drug Induced Lupus
MC drug that causes drug-induced Lupus?: Procainamide
What Ab is made against alpha-methyl dopa?: IgG
G is for Gravida
What Ab is made against Quinide?: IgM
What does IgG activate?: Macrophages to become active
What does IgM activate?: Complement System
MAC
C1-C9
What disease causes leukemoid reaction?: B. pertussis
Scares Pediatricians!!!
>60,000 WBCs
Mononucleosis caused by ------>: EBV
What cell does EBV infect?: B-Cell
What is the marker (receptor) for EBV, B-cells?: CD21
What drug induces atypical lymphocytes?: phenytoin
MOA of Phenytoin?: Blocks intestinal Conjugase
What drug causes macrocytic anemia and atypycal lymph?: Phenytoin
Where does EBV hide for the rest of the life of the patient?: Salivary Glands

Kissing Disease
What test is diagnostic for Mononucleosis?: Anti Heterophile Antibody
What diseases cause eosinophilia?: Strongyloides
Malaria
Type I Yes
whipworm
MCC of Bud-Chiari Sx?: polycytemia vera
Age of ALL?: 0-15
Age of AML?: 15-40
40-60
Age of CLL?: >60
Age of CML?: 40-60
MC overall Leukemia? ------->: CLL
Characteristic of CLL?: MC generalized non-tender lymphadenopathy >60y ?
MC Leukemia >60yo?: CLL
Where does CLL metastisize to?: lymph nodes
49 y.o. 150,000 WBC 1% myeloblasts (<30% blasts) generalized lymphadenopathy: CML
Translocation of CML?: t9;22 of abl gene
49 y.o. 150,000 WBC 1% myeloblasts (<30%) generalized lymphadenopathy: CML
What gene/chromosome is important in CML?: Philadelphia Chromosome 22
What translocation is seen in CML?: t9;22
What is the gene in t9;22?: bcr-abl gene
What two tests are used to Dx CML?: Philadelphia Chromosome (+) and LAP (low level)
LAP = leukocyte alkaline phosphatase not absorbed by malignant cells
What do is the Dx when you see a tear drop cell?: Agnogenic Myeloid Metaplasia
Pt. 4yo, w/ generalized non-tender lymphadenopathy, sternal tenderness, hepatosplenomegaly, fever, normocytic anemia, 50,000 WBCs abnormal appearing cells: ALL
What antigen is use to detect ALL?: CALLA
What does CALLA detect?: B-cells CD10
Pt. 65 yo man, hepatosplenomegalic, 90,000 WBC smudge cells, also pt. has hypogammaglobulinemia: CLL age gives it away
What leukemia has auer rods in it?: AML
What leukemia has lots of auer rods?: Acute Promyelocytic Leukemia (M3)
What are the four/five myeloproliferative dz?: 1. polycythemia vera
2. chronic myelogenous leukemia
3. adenogenic myeloid metaplasia
4. essential thrombocytemia
myelodysplastic Sx
What are the four H's of polycythemia vera?: 1) Hyperviscosity
2) Hypervolemia
3) Histaminemia
4) Hyperuricemia
What is the Dx of a patient that complains of itching after taking a shower hot or cold?: Polycythemia ruba vera
What is the translocation of Burkitt's Lymphoma?: t8;14
What is responsible for Burkitt's Lymphoma?: EBV
What do you see in the pathology slides for Burkitt's?: Starry Sky Appearance
What are the three K for Burkitt's?: Kid 8yo
8 is for translocation 8;14
blacK
C-Myc
What are the stars in Burkitt's?: Macrophages
United States where is Burkitt's Located?: Abdomen (Peyer's Patches, Paraortic Lymph nodes), Testicle also
African Burkitt's lymphoma MC location?: Jaw
What two tissues are resistant to cancer infection?: Cartilage and Elastic Vessels
Pat. w/ plaque like lesions w/ inflamatory cells in epidermis?: Neoplastic epidermis cells Helper T-Cells
Mycosis Fungoides
What is a helper T-cell malignancy that involves skin?: Mycosis Fungoides
What cell is involved in Mycosis Fungoides?: Sezary Body
What is a sezary body?: Helper T-cell seen in plasma of pat. w/ Mycosis Fungoides
What substance is secreted and produced by Gastic Adenocarcinoma (Linitis Plastica)?: Mucin Producer
What is the appearance of the stomach in linitis plastica?: diffusely inflitrative (thickened appearance)
mucosa and muscularis produced rigid thick, leather-bottle gastric wall

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Number of cards 81