Med Chem: General Principles
Terms
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- What is medicinal chemistry?
- A science that explains what drugs do, why they do it and how they do it.
- What are the four componets of the pharmacokinetic phase?
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Absorption
Distribution
Metabolism
Excretion - What are the three phases in the action of drugs?
-
1. Pharmaceutical phase
2. Pharmacokinetic phase
3. Pharmacodynamic phase - What physical state must drugs be in to be absorbed?
- Liquid or Gas
- What determines the amount of absorption of a drug?
- pKa
- What does the rate of the pharmacokinetic phase depend on?
- The drug
- List the routes of administration
-
-Oral administration
-Intramuscular
-Intravenous - Which route of administration avoids first pass metabolism?
- Intravenous injection
- T/F: Most drugs will get into the blood system (systemic circulation)
- True (except steroids)
- What is the site of most drug metabolism?
- Liver
- Are membranes hydrophilic, hydrophobic, lipophilic or lipophobic?
- lipophilic
- Is blood hydrophilic, hydrophobic, lipophilic or lipophobic?
- hydrophilic
-
What type of drugs are susceptible to first pass metabolism?
(hydrophilic, hydrophobic, lipophilic or lipophobic?) - lipophilic drugs
- Explain first pass metabolism
- First pass metabolism is when a drug passes through the liver first before going to the rest of the body (reduces the amount of drug into circulation)
- Everything absorbed from the stomach and intestine (alimentary canal) passes through the liver to become the ___________ vein.
- Hepatic-Portal vein
- What percentage of bile acids are reabsorbed?
- 95%
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_____________ drugs may pass through the liver but will not be significantly effected by 1st pass metabolism?
(hydrophilic, hydrophobic, lipophilic or lipophobic?) - hydrophilic
-
____________ drugs cross membranes and _____________ drugs remain in the system.
(hydrophilic, hydrophobic, lipophilic or lipophobic?) - lipophilic;hydrophilic