FA page 199 G-protein linked 2nd messengers, major functions plus major grouping
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- What is the major function of alpha 1 receptors?
- increase vascular smooth muscle contraction
- What are the major functions (2) of alpha 2 receptors?
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1. decrease sympathetic outflow
2. decrease insulin release - What are the major functions (5) of beta 1 receptors?
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1. increase HR
2. increase contractility
3. increase renin release
4. increase lipolysis
5. increase aqueous humor formation - What are the major functions (3) of beta 2 receptors?
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1. vasodilation
2. bronchodilation
3. increase glucagon release - What is the major function of M1 receptors?
- CNS
- What is the major function of M2 receptors?
- decrease HR
- What is the major function of M3 receptors?
- increase exocrine gland secretions
- What is the major function of D1 receptors?
- relaxes renal vascular smooth muscle
- What is the major function of D2 receptors?
- modulates transmitter release, especially in brain
- What are the major functions (4) of H1 receptors?
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1. increase nasal and bronchial mucus production
2. contraction of bronchioles
3. pruritis
4. pain - What is the major function of H2 receptors?
- increase gastric acid secretion
- What is the major function of V1 receptors?
- increase vascular smooth muscle contraction
- What is the major function of V2 receptors?
- increase water permeability and reabsorption in the collecting tubules of the kidney
- 5 receptors involving Gq?
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"H.A.V.M.M":
1. H1
2. alpha1
3. V1
4. M1
5. M3 (unique in this group) - What happens when a substrate binds to a Gq receptor?
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Gq--> PLC--> lipids cleaved --> PIP2 -->*IP3--> increase Ca
(and) -->*DAG--> PKC
* = branch point - What are the groups of receptors (5) involving Gs?
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"B.V.H. B.D.":
1. beta 2
2. V2
3. H2
4. beta 1 (unique in group)
5. D1 (unique in group) - What happens after a substrate binds to the Gs receptor?
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Gs--> adenylcyclase --> ATP --> cAMP --> INCREASE
PKA - What happens after a substrate binds to the Gi receptor?
- Gi--> adenylcyclase --> DECREASE cAMP --> DECREASE PKA
- What are the groups of receptors (3) involving Gi?
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"A.M.D.":
1. alpha 2
2. M2
3. D2