Fungal Chemotherapy
Terms
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- Amphoteracin B: mode of action
- binds ergosterols (polyene antifungal)
- Amphoteracin B: cidal or static
- fungicidal
- Amphoteracin B: targets
- All systemic fungi (plus penicillium and fusarium?)
- Nystatin: mode of action
- another binds sterols (polyene antifungal)
- Itraconazloe: mode of action
- inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent)
- Itaconazole: cidal or static
- fungistatic
- Itaconazole: targets
- yeasts and molds- dermatophytes, dematiaceous moulds, systemic mycoses
- voriconazole: mode of action
- also inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent)
- Imidazole: mode of action
- also inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent) - toxic problems
- Echinocandins: mode of action
- Inhibits synthesis of B-(1,3)-glucans (cell wall)
- Echinocandins: cidal or static
- fungicidacl (Candida) & fungistatic (Aspergillus)
- Echinocandins: targets
- Candida, Aspergillus
- Flucystosine: mode of action
- Fluorinated pyrimidine analogue (DNA/RNA synthesis)
- Flucosytosine: cidal or static
- Fungistatic (must be used with other therapy)
- Flucosytosine: target
- Candida, Crytococcus
- Terbinafine: mode of action
- An allylamine - inhibits squalene epoxidase, blocks ergosterol synthesis at the squalene
- Terbinafine: target
- dermatomycoses (including onychomycosis) & sporotrichosis, aperfillosis, chromoblastomycosis
- Terbinafine: cidal or static
- fungistatic
- Naftifine: mode of action
- Another allylamine - inhibits squalene epoxidase, blocks ergosterol synthesis at the squalene (topical only)
- Griseofulvin: mode of action
- Disrupts microtubules (with side effects)
- Griseofulvin: tragets
- Dermatophytes (oral aplication)