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USMLE Step 2 Gold Collection


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Albumino-Cytologic Dissociation
Guillain-Barre (markedly increased protein in CSF with only modest increase in cell count)
Antiplatelet Antibodies
Idiopathic thrombocytopenic purpura
Aschoff Bodies
Rheumatic fever
Auer Rods
Acute promyelocytic leukemia (AML type M3)
Sickle cell anemia: switch a glu to val in β chain
Low O2 ↑ sickling
Aplastic crisis w/ B19 (Parvovirus ssDNA) infection
Salmonella osteomyelitis
Vaso-occlusive painful crisises
Hydroxyurea as Txt (↑ HbF) & Bone marrow transplant
UMN lesion
Basophilic Stippling of RBCs
Lead poisoning
Bence Jones Protein
Multiple myeloma free light chains (either kappa or lambda)
Waldenstrom's macroglobinemia
Birbeck Granules
Histiocytosis X (eosinophilic granuloma)
Blue Bloater
Chronic Bronchitis (at least 3 months for at least 2 years of ecessive mucus secretion & chronic
recurrent productive cough)
Boot-Shaped Heart
Tetralogy of Fallot
Bouchard's Nodes
Osteoarthritis (Proximal IP joint of the fingers)
Boutonniere's Deformity
Rheumatoid arthritis flex proximal & extend distal IP joints
Brown Tumor
Call-Exner Bodies
Granulosa cell tumor: associated w/ endometrial hyperplasia & carcinoma
Granuloma-Theca cell tumor
Cardiomegaly with Apical Atrophy
Chagas' Disease
1° Syphilis
Haemophilus ducreyi
Charcot Triad
Multiple sclerosis = nystagmus, intention tremor, scanning speech
Charcot-Leyden Crystals
Bronchial asthma
Cheyne-Stokes Breathing
Cerebral lesion
Chocolate Cysts
Chvostek's Sign
Hypocalcemia facial spasm in tetany
Clue Cells
Gardnerella vaginitis
Codman's Triangle
Cold Agglutinins
Mycoplasma pneumoniae
Infectious mononucleosis
Condyloma Lata
2° Syphilis
Cotton Wool Spots
Aka, cytoid bodies seen w/ SLE (yellowish cotton wool fundal lesions)
Councilman Bodies
Dying hepatocytes - HepB
Crescents In Bowman's Capsule
Rapidly progressive (crescentic glomerulonephritis)
Currant-Jelly Sputum
Curschmann's Spirals
Bronchial asthma
Depigmentation Of Substantia Nigra
Donovan Bodies
Granuloma inguinale (STD)
Osteoarthritis (polished, ivory-like appearance of bone)
Ectopia Lentis
Erythema Chronicum Migrans
Lyme Disease
Fatty Liver
Ferruginous Bodies
Asbestosis - & Iron laden
Ghon Focus / Complex
Tuberculosis (1° & 2°, respectively)
Glitter Cells
Acute Pyelonephritis
Gower's Maneuver
Duchenne's MD use of arms to stand
Heberden's Nodes
Osteoarthritis (Distal IP joint of the fingers)
Heinz Bodies
G6PDH Deficiency
Heterophil Antibodies
Infectious mononucleosis (EBV)
Hirano Bodies
Hypersegmented PMNs
Megaloblastic anemia
Hypochromic Microcytic RBCs
Iron-deficiency anemia or β Thalassemia
Jarisch-Herxheimer Reaction
Syphilis over-aggressive treatment of an asymptomatic pt. that causes symptoms 2° to rapid lysis
Joint Mice
Osteoarthritis (fractured osteophytes)
Kaussmaul Breathing
Acidosis / Diabetic Ketoacidosis
Keratin Pearls
Squamous Cell CA of skin Actinic Keratosis is a precursor
Keyser-Fleischer Ring
Kimmelstiel-Wilson Nodules
Diabetic nephropathy: Nodular Glomerulosclerosis nodules of mesangial matrix
HPV 6 & 11 (condyloma acuminatum - benign) and HPV 16 & 18 (malignant association)
Koplik Spots
Lewy Bodies
Parkinson's (eosinophilic inclusions in damaged substantia nigra cells)
Lines of Zahn
Arterial thrombus
Lisch Nodules
Neurofibromatosis (von RecklinhausenÂ’s disease) = pigmented iris hamartomas
Lumpy-Bumpy IF Glomeruli
Poststreptococcal glomerulonephritis - prototype of nephritic syndrome
Mallory Bodies
Alcoholic hepatitis
McBurney's Sign
Appendicitis (McBurney's Point is 2/3 of the way from the umbilicus to anterior superior iliac spine)
Michealis-Gutmann Bodies
Malakoplakia lesion on bladder due to macros & calcospherites (M-G Bodies): usually due to E. Coli
Monoclonal Antibody Spike
Multiple myeloma this is called the M protein (usually IgG or IgA) MGUS
Negri Bodies
Neuritic Plaques
Neurofibrillary Tangles
Non-pitting Edema
Myxedema Anthrax Toxin
Notching of Ribs
Coarctation of Aorta
Nutmeg Liver
CHF = causing congested liver
Owls Eye Cells
CMV Reed Sternburg Cells (Hodkins Lymphoma) Aschoff cells seen w/ Rheumatic Fever
Painless Jaundice
Pancreatic CA (head)
Rheumatoid arthritis, also see morning stiffnes that ↓ w/ joint use, HLA-DR4
Pautrier's Microabscesses
Mycosis fungoides (cutaneous T-cell lymphoma), Sezary
Philadelphia Chromosome
Pick Bodies
Pick's Disease
2 types of COPD
Pink Puffer -Type A: Emphysema
Blue Bloater – Type B: Bronchitis
Emphysema Centroacinar= smoking Panacinar - α1-antitrypsin deficiency
Gout (MP joint of hallux)
Port-Wine Stain
Posterior Anterior Drawer Sign
Tearing of the ACL
Psammoma Bodies
Papillary adenocarcinoma of the thyroid
Serous papillary cystadenocarcinoma of the ovary
Punched-Out Bone Lesions
Multiple myeloma
Rash on Palms & Soles
2° Syphilis
Coxsackie virus infection: Hand-Foot-Mouth Disease
Red Morning Urine
Paroxysmal nocturnal hemoglobinuria. You would use Ham's test to confirm.
Reed-Sternberg Cells
Hodgkin's Disease
Reid Index Increased
Chronic bronchitis = ↑d ratio of bronchial gland to bronchial wall thickness
Reinke Crystals
Leydig cell tumor
Rouleaux Formation
Multiple myeloma RBC's stacked as poker chips
S3 Heart Sound
L→R Shunt (VSD, PDA, ASD)Mitral Regurg LV Failure
S4 Heart Sound
Pulmonary Stenosis Pulmonary HTN
Schwartzman Reaction
Neisseria meningitidis impressive rash with bugs
Smith Antigen
SLE (also anti-dsDNA)Malar Rash, Wire loop kidney lesions, Joint pain, False (+) syphilis test (VDRL)90% 14-45 yo females also seen w/ use of INH, Procainamide, Hydralazine = SLE-like syndrome
Soap Bubble on X-Ray
Giant cell tumor of bone
Spike & Dome Glomeruli
Membranous glomerulonephritis = Nephrotic syndrome Spike = basement membrane material & Dome = immune complex deposits (IgG orC3)
String Sign on X-ray
Crohn's bowel wall thickening
Target Cells
Thalassemia in α Thalassemia w/ no α gene: Hydrops Fetalis & Intrauterine death associations = HbBarts
Tendinous Xanthomas
Familial Hypercholesterolemia
Thyroidization of Kidney
Chronic pyelonephritis
Tram-Track Glomeruli
Membranoproliferative GN: Nephritic syndrome - basement membrane is duplicated into 2 layers
Trousseau's Sign
Visceral ca, classically pancreatic (migratory thrombophlebitis) Hypocalcemia (carpal spasm) These are two entirely different disease processes and different signs, but they unfortunately have the same
Virchow's Node
Supraclavicular node enlargement by metastatic carcinoma of the stomach
Warthin-Finkeldey Giant Cells
WBC Casts
. Pyelonephritis
Whipple's Triad
CNS disfunction Hypoglycemic episodes glu injection reverses CNS Sympts
Wire Loop Glomeruli
Lupus nephropathy, type IV (diffuse proliferative form)
↑ AFP in amniotic fluid or mother's serum
Spina Bifida
↑ Uric Acid
Gout Lesch Nyhan Myeloproliferative Disorders Diuretics (Loop & Thiazides)
"Ground Glass" on chest x-ray
Due to Pneumocystis carinii Seen w/ Atelectasia
Honey Combing of the lung
Seen w/ Asbestosis (a restrictive lung disease)
Goodpastures syndrome (pneumonia w/ hemoptysis & rapidly progressive glomerulonephritis)
Linear Ig Deposits
Goodpastures syndrome
45 Degree Branch Points
PAS(+) Dutcher Bodies
Waldenstrom's Macroglobulinemia = ↑IgM = Hyperviscosity
Ground Glass in Abdomen(Hyaline)
Seen in the hepatocytes of healthy carriers of HBsAg in liver biopsies
Signet Ring Cells
Cells that replace the ovaries, due to Krukenberg's tumor that has metastasized from the stomach
Ground Glass Appearance (Hyaline)
Seen w/ Progressive Multifocal Leukoencephalopathy oligodendrocytes Nuclei seen in Papillary CA of the thyroid (malignant)
Congo Red
Shows amyloid deposition in plaques & vascular walls
Meningiomas & Progesterone
Some meningiomas have Progesterone receptors = rapid growth in pregnancy can occur
Tuberous Sclerosis Triad
Seizures, Mental retardation, Leukoderma (congenital facial white spots or macules):
Cowdry A Inclusions
Seen w/ Herpes Simplex Encephalitis - in oligodendroglia
Devic's Syndrome
Neuromyelitis Optica A variant of multiple sclerosis: rapid demyelination of the optic nerve & spinal cord w/ paraplegia
c-erb B2
Breast Cancer association
Foster-Kennedy Syndrome
A tumor causing blindness & loss of smell w/ papilloedema
Hoffman's Sign
Flicking of the middle fingers nail
Red Nucleus Destruction
Intention tremors of the arm
Ventral Spinocerebellar tr.
Unconscious proprioception of lower extremities
Dorsal Spinocerebellar tr.
Unconscious prorpioception & fine motor movements
Cuneocerebellar tr.
Unconscious proprioception & fine motor movements of upper extremities
Dorsal Column
Conscious proprioception of the body
Taste & Smell
Muscles of the eye & of the tongue
Sensation of tongue, soft palate. Carotid Body & Sinus innervation
Edinger Westphal = parasympathetic eye innervation Gland innervation = secretions Viscera
Innervation of muscles of masticaiton, facial expressions, larynx & pharynx
LMN Lesion
Werndig Hoffman (progressive infantile muscular atrophy).Poliomyelitis
Sensory Pathway Lesion
Subacute Combined Degeneration = Friedrich's Ataxia = B12 deficiency
Tabes Dorsalis (Neurosyphilis)
Both UMN & LMN Lesion
ALS = Lou Gherig's Disease
Both Sensory & Motor Lesion
Brown Sequard. Anterior Spinal artery Occlusion
Pain & temperature of face
Sensation of external ear
Arcuate Nucleus
Releases PIF (dopa-ergic neurons)
Mamillary Body
Can have hemorrhages as seen in Wernicke's Encephalopathy
RBSc w/ spiny projections. Seen in Abetalipoproteinemia.
Suprachiasmatic Nucleus
Controls circadian rhythm
Ventromedial Nucleus
Satiety center. Savage behavior & obesity when lesioned
Lateral Nucleus
Induces eating. Starvation when lesioned

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