eicosanoid I
Terms
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-
COXI?
COX2?
LT? -
GI protectant
cause inflammatory mediators
pro-inflammatory - cAMP/DAG pathway?
- LTD4
- cAMP pathways only?
- DIE
- - platelet agg?
- I2, E2
- chemotactic?
- LTB4
- vasodilation?
-
LTC4, LTD4
DIE - vasoconstriction?
- TXA2
- if inhibit COX actiivty, what happens to LT activity?
- inc.
- broncho-constriction?
- LTC4, LTD4
- PGE2 relaxes what?
- uterus, circular
- PGE2 contracts what?
- pregnancy, longitudinal
- what inc. RBF, GFR, diuresis, renin secretion?
-
PGE2, I2
(TxA2 does the opposite) - What 2 always constricts?
-
PGF2alpha
TXA2 - protects gastric mucosa?
- E2, IE
- CNS: inc. body temp, fever?
- E2