chapter 1
Terms
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- primary structure
- AA sequence
- uncommon AA stores E in muscle
- creatine
- uncommon AA (metabolize fatty acids)
- carnitine
- structure of AA backbone (physiological cond)
- h3n+--ch--coo-
- zwitterion
- has + and - charge on same ion
- pk2
- proton at NH3 group
- uncommon AA (bile acid)
- taurine
- alpha helix
- backbone makes helix, r groups stick out
- non polar AA's
- glycine, alanine, proline, valine, leucine, isoleucine, methionine
- pI of neutral AA
- pk1 + pk2 / 2
- beta sheet
- zig zag arrangement with parallel or anitparallel options
- pka of histidine & relevance
- ~7 active site of enzymes, catalyst, (protonated or deprotonated)
- uncommon AA in urea cycle
- citrulline
- aromatic AA's
- phenylalanine, tyrosine, tryptophan
- essential AA's
- met, iso, leu, val, thr, cys, phe, tyr, try, lys, arg, his (PVT TIM HALL)
- pI
- pH at which ion is neutral
- protein
- mw > 10,000 g/mol
- Neg AA's (acidic)
- Aspartate, glutamate
- secondary structure
- organization w/in polypeptide (helix, sheet)
- midpoints of a titration curve
- pk's
- quaternary structure
- multi-subunit protein (not always present)
- other uncommon AA's
- 5-hydroxylysine, carboxyglutamate, ornithine
- pI of pos charged AA
- pk2 + pkr / 2
- endpoints of a titration curve (where?)
- pH levels off
- which sterioisomer are AA's found in (nature)
- L
- formation of peptide bond (what type of rxn)
- dehydrogenation
- covalent stablizing forces
- disulfide bond
- pI of neg charged AA
- pk1 + pkr / 2
- uncommon AA not post-translated
- selenocystine
- noncovalent stablilizing forces
- H bond, hydrophobic, ionic, van der waals
- tertiary structure
- whole polypeptide including prosthetic groups
- hydrophobic AA's are
- nonpolar
- polar AA's
- Serine, threonine, cysteine, asparagine, glutamine
- Non-covalent interactions in aq. soln
- H bond, ionic bond, hydrophobic, van der waals
- read AA chains this direction
- N to C terminus
- positive AA's (basic)
- lysine, argnine, histidine
- pk1
- proton at carboxyl group
- 4 groups of biomolecules
- protein, carb, lipid, nucleic acids
- polypeptides
- mw < or = 10,000 g/mol
- oligopeptides
- small polymers (a few AA's)
- hydrophilic AA's are
- polar