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Michaelangelo

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Dermatitis
A group of inflammatory puritic skin dosorders. Etiology: allergy (usually type 4 hypersensitivity), chemical injury, or infection.
What are the 3 main etiologies of Dermatitis
allergy (usually type 4 hypersensitivity), chemical injury, and infection
What is atopic dermatitis (escema)
Puritic eruption, mainly on flexor surfaces. Often associated w/other atopic diseases (asthma, allergic rhinitis).
What is atopic dermatitis associated with? (2)
asthma, allergic rhinitis
What do you call a puritic eruption, mainly on flexor surfaces.
atopic dermatitis
Allergic contact dermatitis
Type IV hypersensitivity reaction that follows exposure to allergen (poison ivy, poison oak, nickel, rubber, chemicals). Lesions occur at site of contact.
What is the name for the type IV hypersensitivity reaction of the skin that follows exposure to allergen
Allergic contact dermatitis
Where is the lesion following exposure in allergic contact dermatitis
the site of contact
What is psoriasis
Epidermal hyperplasia (acanthosis) with parakeratotic scaling (nuclei still in stratum corneum) espcially on the knees and elbos. Increased stratum spinosum. Decreased stratum granulosum. Auspitz sign.
What are the histologic features of psoriasis (4)?
Epidermal hyperplasia: nuclei still in stratum corneum. Increased stratum spinosum. Decreased stratum granulosum
What skin condition presents with Auspitz sign?
Psoriasis
What skin condition is characterized by Epidermal hyperplasia: nuclei still in stratum corneum. Increased stratum spinosum. Decreased stratum granulosum
Psoriasis
What skin condition is often found on knees and elbows
Psoriasis
What skin condition presents with parakeratotic scaling?
Psoriasis
What is parakeratotic scaling?
nucli still in stratu corneum.
What is dermatitis herpetiformis
Pruritic papules and vesicles. Associated with celiac disease.
What skin condition is associated with celiac disease?
dermatitis herpetiformis
What skin condition presents with pruritic papules and vesicles?
dermatitis herpetiformis
What is Lichen planus
Pruritic, purple, polygonal papules; infiltrate of lymphocytes at dermoepidermal junction
What skin condition presents with pruritic, purple, polygonal papules
Lichen planus
What skin condition is histologically characterized by infiltrate of lymphocytes at dermoepidermal junction
Lichen planus
What is erythema multiforme associated with (4 conditions). What is the clincial presentation (4) features.
Associated with infectons, drugs, cancers and autoimmune disease. Presets with mutiple types of lesions, including macules, papules, vesicles, and target leisons (red papules with a pale center).
What skin condition presents with macules, papules, vesicles, and target leisons
erythema multiforme
What skin condition is associated with infectons, drugs, cancers and autoimmune disease
erythema multiforme
What is the major form of erythema multiforme?
Stevens-Johnson syndrome
What are the characterizes Stevens-Johnson syndrome (5)?
high fever, bulla formation and necrosis, ulceration of the skin and a high mortality
What type of skin syndrom is Stevens-Johnson syndrome
Erythema multiforme
What is Seborrheic keratosis?
Flat, pigmented squamous epithelial proliferation with keratin-filled cysts (horn cysts). Benign.
What skin condition presents with flat, pigmented squamous epithelial proliferation with keratin-filled cysts (horn cysts)
Seborrheic keratosis
What is the prognosis for Seborrehic keratosis?
Good, it's benign.
What is Actinic keratosis?
Caused by suun exposure. Small, rough, erythematous or brownish papules. Premalignant lesion. Risk of carcinoma is proportional to epithelial dysplasia.
How does Actinic keratosis present clinically?
Small, rough erythematous or brownish papules.
Where is Actinic keratosis on the spectrum of malignant transformation?
Pre-malignant
What is the cause of actinic keratosis
Sun exposure
What skin condition does sun exposure lead to?
actinic keratosis
What determines the risk of pregression to carcinoma in actinic keratosis?
risk is proportional to epithelial dysplasia
What is keloid
Tumor of connective tissue elemets of dermis that causes raised, thickened scars. Follows trauma to skin, especically in African-Americans
What skin condition are African-Americans pre-disposed to
keloid
What is the clinical presentation of keloid?
Tumor of raised thickened scars
What skin condition presents with a tumor of raised thickend scars
keloid
What skin condition follows trauma to skin?
keloid
What a tumor of connective tissue elemets of dermis called
keloid
What are the histologic features of keloid
tumor of connective tissue elemts of demis.
Bullous pemphigoid
Autoimmune disorder with IgG antibody against epidermal basement membrane (linear immunoflouresce). Similar to but less sever than pemphigus vultgaris - affects skin but spares orgal mucosa.
What skin condition is an autoimmune disorder with IgG antibody against epidermal basement membrane
Bullous pemphigoid
How would you test for bullous pemphigoid
Use immunoflourescent anti-human antibodies. Look for a linear pattern along the epidermal basement membrane.
What skin disorder does a linear immunoflourescent pattern along the basement membrane point to?
bullous pemphigoid
What is the clinical presentation of bullous pemphigoid?
affects skin but spares oral mucosa.
What is the difference between bullous pemphigoid and pemphigus vulgaris
bullous pemphigoid affects the skin but spares the oral mucosa, pemphigus vulgaris invovles the oral mucosa and skin
What ar two autoimmune skin disorders?
bullous pemphigoid and pemphigus vulgaris
What is pemphigus vulgaris?
Potentially fatal autoimmune skin disorder. Intradermal bullae involving the oral mucosa and skin.
What are the histologic findings in pemphigus vulgaris?
acanthosis (breakdown of epithelial cell-to-cell junctions), IgG antibody agaist epidermal cell surface (immunofluorescence througout epidermis).
What is the immunoflourescence presentation of pemphigus vulgaris vs. bullous pemphigoid
Pemphigus vulgaris has immunofluorescence througout epidermis, bullous pemphigoid only has immunoflourescence along the epidermal basement membrane (linear pattern).
What skin disease presents with acanthosis (breakdown of epithelial cell-to-cell junctions), IgG antibody agaist epidermal cell surface (immunofluorescence througout epidermis).
Pemphigus vulgaris
What skin condition presents with numerous crusted, denuded and weepy erythematous plaques all over the body and vesicles on the gingiva
Pemphigus vulgaris
What skin condition presents with erythematous plaques contiguous with large bullae
Bullous pemphigoid
What does the patient with pemphigus vulgaris look like? (3 features)
numerous crusted, denuded and weepy erythematous plaques all over the body and vesicles on the gingiva
What is the physical finding in the patient with bullous pemphigiod
erythematous plagues contiguous with large bullae
What is the type of autoantibody seen in bullous pemphigiod and pemphigus vulgaris
IgG
Which condition is more sever bullous pemphigoid or pemphigus vulgaris
pemphigus vulgaris

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