z-Pharm Stroke
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- List five reversible dementias?
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1. alcholic dementia
2. normal pressure hydrocephalus
3. drug toxicity
4. pseudodementias
5. dementias caused by nutritional defects - In Alzeheimers, what neuronal system has a lot of degeneration?
- The cholinergic neurons in the "nucleus basalis of Meynert"
- What is the major genetic problem found in familial alzheimers?
- Increased production of amyloid precursor proteins.
- What are type of drugs are tacrine (Cognex), Aricept, and Exelon?
- Cholinergic degradation inhibitors used to treat Alzheimers.
- What is Cevimeline?
- A direct cholinergic agonist used to treat Alzheimers.
- For Alzeheimers disease, what three things can be given to the patient either prior to the disease or right at the onset as preventative medicine?
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1. PRESENLINS 1 and 2
2. Estrogen
3. NSAIDS - What is Ciliary neurotrophic factor given to treat?
- Huntington's disease
- What is Riluzole and what is it given to treat?
- Riluzole is a Na channel blocker given to treat Px with Amyotrophic Lateral Sclerosis (ALS). It prolongs life.
- Four dementias due to cardiovascular disorders are:
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1. Atherosclerosis (large vessel)
2. arteriosclerosis (small vessel)
3. Embolisms
4. Strokes - What is the treatment for Atherosclerosis induced dementia?
- Diet and anti-hyperlipoproteinemia drugs (clofibrate, cholestyramine, "STATINS")
- What type of drugs are given to treat arteriosclerosis?
- Anti-hypertensives
- What two drugs are given in the acute treatment of non-hemorrhagic strokes?
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Recombinant tissue plasminogen activator (rt-PA)
and
Streptokinase - What is given to reduce hypothyroidism induced dementia?
- Synthroid
- What is given to reverse Cushing's syndrome induced dementia?
- Mifepristone (glucorticoid antagonist)
- When you are doing a work up for Alzheimers disease what two types of neuroimaging are ordered?
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Head CT scan without contrast
Head MRI without contrast