hematology/oncology
Terms
undefined, object
copy deck
- 4 causes of microcytic anemia
-
TICS
thalessemia
iron deficiency
chronic disease
sideroblastic anemia - elderly male with hypochromic, microcytic anemia is asymptomatic
- FOBT and sigmoidoscopy - colon ca until proven otherwise
- precipitants of hemolytic crisis in patients with G6PD deficiency
- sulfonamides, antimalarials, fava beans
- most common inherited hemolytic anemia
- hereditary spherocytosis
- diagnostic test for hereditary spherocytosis
- osmotic fragility test
- pure rbc aplasia
- diamond-blackfan anemia
- anemia associated with absent radii and thumbs, diffuse hypopigmentation, café au lait spots, microcephaly, and pancytopenia
- fanconi's anemia
- medications and viruses that cause aplastic anemia
- chloramphenicol, sulphonamides, radiation, HIV, chemo, hepatitis, parvo B19, EBV
- how to distinguish polycythemia vera from secondary polycythemia
- both have increased hct and rbc mass, but PV should have normal SaO2 and low erythropoietin
- TTP pentad
-
FAT RN
fever
anemia/splenomegaly
TCP
renal failure (acute)
neurologic changes - HUS triad
-
anemia
TCP
ARF - treatment for TTP
- emergent large volume plasmapheresis, corticosteroids and anti-platlet drugs
- which of the following oare elevated in DIC: fibrin split products, D-dimer, fibrinogen, platelets, hct
- d-dimer and fibrin split products
- treatment for ITP in children
- usually resolves spontaneously - may require IVIG or steroids
-
8 y/o boy presents with hemarthrosis, increased PTT with normal PT and BT
Dx? Rx? - hemophilia A or B: consider desmopressin (for hemophilia A) factor VIII or IX supplements
- 14 y/o girl presents with prolonged bleeding after ddental surgery and with menses, normal PT, normal/increased PTT, increased BT. Dx? Rx?
- vWF disease - desmopressing, FFP, or cryoprecipitate
- 60 y/o African-American male presents with bone pain. w/u for myeloma might reveal...?
- monoclonal gammopathy, bence-jones proteinuria, 'punched out' lesions on Xray
- reed-sternberg cells
- Hodgkin's lymphoma
- 10 y/o boy presents with fever, wt loss, and night sweats. Exam shows ant. mediatstinal mass. suspected Dx?
- NHL
- microcytic anemia with decreased serum iron, decreased TIBC, normal/increased ferritin
- anemia of chronic disease
- microcytic anemia with decreased serum iron, decreased ferritin, increased TIBC
- iron defeciency anemia
- 80 y/o male with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis. suspected Dx?
- CLL
- late, life-threatening complication of CML
- blast crisis - bone pain, fever, splenomegaly, and pancytopenia
- auer rods on blood smear
- AML
- AML subtype associated with DIC
- M3
- electrolyte changes in tumor lysis syndrome
-
decreased Ca
increased K, PO4, uric acid - treatment for AML M3
- retinoic acid
- 50 y/o male presents with early satiety, splenomegaly, and bleeding. Cytogenetics show t(9,22). Dx?
- CML
- Heinz bodies
- intracellular inclusions - thalassemia, G6PD, and post-splenectomy
- autosomal-recessive disorder with a defect in GPIIbIIIa platlet receptor and decreased platlet aggregation
- Glanzmann's thrombasthenia
- virus associated with aplastic anemia in patients with sickle cell anemia?
- parvovirus B19
- 25 y/o African-American male with sickle cell anemia has sudden onset of bone pain. Management of pain crisis?
- O2, analgesia, IV fluids, transfusion if severe
- significant cause of morbidity in thalassemia patients. treatment?
- Iron overload - deferoxamine