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Bronchodilators in regards to respiratory therapy (copy)


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Parasympatholytic drugs used for bronchodilation
1) Atropine sulfate or atropine
2) ipratropium bromide (Atrovent)
3) ipratroprium bromide & albuterol *a sympathomimetic (Combivent)
List the 3 drug classes for Sympathomimetic bronchodilation.
1) Catecholamines
2) Resorcinols
3) Saligenins
Drugs included in the catecholamine class
1) epinephrine (Adrenalin, Primatene Mist)
2) racemic epinephrine (Vaponefrin, Micronefrin, and AsthmaNefrin)
3) isoproternol (Isuprel, Isuprel Mistometer)
4) isoetharine (Bronkosol, Bronkometer)
5) bitolterol (Tornalate) *also a Pro-drug
6) formoterol
Drugs included in the resorcinol class
1) metaproternol (Alupent, Metaprel)
2) terbutaline (Brethine, Bricanyl, Brethine, and Bambuterol *also a pro-drug)
Drugs included in the saligenin class
1) albuterol (proventil, ventolin)
2) pirbuterol (Maxair)
3) salmeterol (Serevent)
4) levalbuterol (xopenex)
Trade name: Maxair (MDI)
Class: saligenin
ROO: 5-8 mins.
DOA: 5 hrs.
Avail as an MDI, PO 10-15 mg or syrup 7.5mg/5ml
Receptor: (ß2>ß1)
Trade name: Serevent (DPI or MDI)
Class: Saligenin
ROO: 20 min.
DOA: 12 hours
Receptor: (ß2)
Trade names: Adrenalin (Neb), Primatene Mist (MDI)
Class: Catecholamine
ROO: 3-5 min
DOA: 1-3 hrs.
Receptor: (a,ß)
Racemic Epinephrine
Trade name: Vaponefrin (Neb), Micronefrin (Neb), AsthmaNefrin (Neb)
Class: Catecholamine
ROO: 3-5 min
DOA: 30 min-2 hr
Receptor: (a,ß)
Trade name: Isuprel (Neb), Isuprel-Mistometer (MDI)
Class: Catecholamine
ROO: 2-5 min
DOA: 30min-2 hr
Receptor: (ß1,ß2)
Trade name: Bronkosol (Neb), Bronkometer (?)
Class: Catecholamine
ROO: 1-6 min
DOA: 1-3 hr
Receptor: ß2>ß1
Trade name: Tornalate (MDI)
Class: Catecholamine Pro-drug
ROO: 3-4 min
DOA: 5-8 hr
Receptor: ß2>ß1
Trade name: Alupent (Neb), Metaprel (MDI)
Class: Resorcinol
ROO: 1-5 min
DOA: 6 hr
Receptor: ß2>ß1
Trade name: Brethine, Brethaire (MDI), Bricanyl, and Bambuterol (bambuterol is a pro-drug)
Class: Resorcinols
ROO: 5-30 min
DOA: 3-6 hr
Receptor: ß2>ß1
Trade name: Proventil (MDI, DPI, Neb), Ventolin (MDI, DPI, Neb)
Class: Saligenin
ROO: 15 min
DOA 3-6 hr
Receptor: ß2>ß1
Trade name: Xopenex (Neb)
Class: Saligenin
ROO: 15
DOA: 3-8 hr
Receptor: ß2>ß1
Trade name: Foradil
Class: Catecholamine
What happens when caecholamines are exposed to heat and light?
They become inactivated which will cause them to be antagonists or beta blockers. This could have serious consequences in an emergency.

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