HYPERLIPIDEMIA-BOOK
Terms
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- Type 1 hyperlipoproteinemia treatment
- Limit total daily fat intake to no more than 10-25g/day
- Type IIa hyperlipoproteinemia treatment
-
-HMG-Co-ARI
-Cholestyramine/colestipol
-Niacin - Type IIb hyperlipoproteinemia treatment
-
-Statins
-Fibrates
-Niacin - Types III, IV, V treatment
-
-Fibrates
-Niacin - Niacin MOA
- Reduces VLDL synthesis -> reduces LDL synthesis
- Niacin side effects
-
-cutaneous flushing
-hyperuricemia
-hyperglycemia
-increased LFTs
-acanthosis nigricans - Concomitant use of what should be avoided at the time of ingestion of niacin due to increased flushing and pruritus
-
-alcohol
-hot drinks - Bile acid resins MOA
- Stimulates hepatic bile acid synthesis from cholesterol--> increases cholesterol biosynthesis-->increases number of LDL receptors on hepatocyte
- Bile acid resins side effects
- -bloating, flatulence, constipation
- Bile acid resins may aggravate this condition
- hypertriglyceridemia; due to increased hepatic cholesterol biosynthesis paralled by increased VLDL production