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mcb lecture 14 - MT

mcb terms

Terms

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MT
ER organized and transported by _____.
myosin heads in muscle
dynein heads function similarly to ____
+
polarity of MTs in axons is ____
cytosolic dyneins
mainly minus end directed motors
kinesin, dynein
_____ (MT?) bind by themselves, _____ do not. need accessory proteins.
tau
if bad, nastifies the brain in alzeihmers, tangles the neurons
MT sliding
mechanism of ciliary motility
MTOC, microtubule organizing center
in living cells, ends of MT are functionally capped with _____.
kinesin-1
the walking movement of _____ along MT. processive, heads swing over one another.
axonemal dynein
large protein assemblies, two or three heavy polypeptide chains, make up globular dynein heads
forward throwing
conformational changes resulting from MT binding as well as ATP hydrolysis result in ____ _____ of one head at a time. (kinesin heads)
single MT
railroads, bi directional
dynein
motor, an ATPase (in MT cilia)
curvy, straight
when GTP cap is not present, the MTs grow ____, otherwise _____
9 + 2
9 outer doublets, 2 singlet MT in center
MT
1 alpha tubulin + 1 beta tubulin = ?
MT specific drugs
bring to MTs and make them super nondynamic. thwart mitosis, slow cancer. also targets the gut and other quickly growing cells
situs inversus
flipped organ placement.
gamma tubulin ring complex
bings to - ends of MT in centrosomes
melanophores
cells found in skin of some amphibians and fish and contain numerous membrane bound pigment granules.
dynactin
dynein receptor, helps cytoplasmic dyneins to attach to membrane bound organelles
-, +
usually, ____ ends are proximal to the MTOC and the ____ ends are distal (MT polarity)
KS, kartagener syndrome
defective, non productive cilia motility. patients have chronic resp. disease (ineffective mucus clearance), immotile sperm (infertile), situs inversus
MT
organize cells, trafficking of membrane bound organelles, movement of cilia/flagella and chromosomes
+, -
in cilia and flagella, ____ ends are out near the tip and ____ ends at the BB
MT
golgi uses ____ for organization
MT favorable conditions
conc. of subunits, warm T, low calcium, GTP, MAPs
centrioles
core of MTOC is pair of ____.
nexin
connects all the out doublets
+ end
end of MT that grows faster
9 triplet pairs
centriole pairs are made up of ______
axoneme
core of cilia or flagella
kinesins
mainly plus end directed motors
BB, basal body
9 triplet MT arragnement, identical to centriole. And B tubules continuous with axonemal outer doublets. acts as a nucleating center for axoneme.
cilia/flagella, membrane/organelle traffic, mitotic spindle
three primary ex. of MT motility
treadmilling
net assembly at plus end, net disassembly at minus end (MT)
kinesins
_____ slide along MT with their globular heads
MT
long hollow tubes, average diameter 25nm
GTP
MT ends with ____ subunits are more stable than those without
MAPS
help MTs in assmebly, stabilization, crossbiridging, mediating etc

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