mcb lecture 14 - MT
mcb terms
Terms
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- MT
- ER organized and transported by _____.
- myosin heads in muscle
- dynein heads function similarly to ____
- +
- polarity of MTs in axons is ____
- cytosolic dyneins
- mainly minus end directed motors
- kinesin, dynein
- _____ (MT?) bind by themselves, _____ do not. need accessory proteins.
- tau
- if bad, nastifies the brain in alzeihmers, tangles the neurons
- MT sliding
- mechanism of ciliary motility
- MTOC, microtubule organizing center
- in living cells, ends of MT are functionally capped with _____.
- kinesin-1
- the walking movement of _____ along MT. processive, heads swing over one another.
- axonemal dynein
- large protein assemblies, two or three heavy polypeptide chains, make up globular dynein heads
- forward throwing
- conformational changes resulting from MT binding as well as ATP hydrolysis result in ____ _____ of one head at a time. (kinesin heads)
- single MT
- railroads, bi directional
- dynein
- motor, an ATPase (in MT cilia)
- curvy, straight
- when GTP cap is not present, the MTs grow ____, otherwise _____
- 9 + 2
- 9 outer doublets, 2 singlet MT in center
- MT
- 1 alpha tubulin + 1 beta tubulin = ?
- MT specific drugs
- bring to MTs and make them super nondynamic. thwart mitosis, slow cancer. also targets the gut and other quickly growing cells
- situs inversus
- flipped organ placement.
- gamma tubulin ring complex
- bings to - ends of MT in centrosomes
- melanophores
- cells found in skin of some amphibians and fish and contain numerous membrane bound pigment granules.
- dynactin
- dynein receptor, helps cytoplasmic dyneins to attach to membrane bound organelles
- -, +
- usually, ____ ends are proximal to the MTOC and the ____ ends are distal (MT polarity)
- KS, kartagener syndrome
- defective, non productive cilia motility. patients have chronic resp. disease (ineffective mucus clearance), immotile sperm (infertile), situs inversus
- MT
- organize cells, trafficking of membrane bound organelles, movement of cilia/flagella and chromosomes
- +, -
- in cilia and flagella, ____ ends are out near the tip and ____ ends at the BB
- MT
- golgi uses ____ for organization
- MT favorable conditions
- conc. of subunits, warm T, low calcium, GTP, MAPs
- centrioles
- core of MTOC is pair of ____.
- nexin
- connects all the out doublets
- + end
- end of MT that grows faster
- 9 triplet pairs
- centriole pairs are made up of ______
- axoneme
- core of cilia or flagella
- kinesins
- mainly plus end directed motors
- BB, basal body
- 9 triplet MT arragnement, identical to centriole. And B tubules continuous with axonemal outer doublets. acts as a nucleating center for axoneme.
- cilia/flagella, membrane/organelle traffic, mitotic spindle
- three primary ex. of MT motility
- treadmilling
- net assembly at plus end, net disassembly at minus end (MT)
- kinesins
- _____ slide along MT with their globular heads
- MT
- long hollow tubes, average diameter 25nm
- GTP
- MT ends with ____ subunits are more stable than those without
- MAPS
- help MTs in assmebly, stabilization, crossbiridging, mediating etc