embryology-03-third and fourth weeks
Terms
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- main developmental task during the third week?
- gastrulation – third tissue layer appears
- 3rd & 4th weeks – events?
- bilaminarà trilaminar (3rd tissue layer appears), complex three dimensional changes & organogenesis begin
- When does the primitive streak form?
- 13 – 14 days after fertilization
- What is the primitive streak?
- a thickening of epiblast layer in the midline
- cause of primitive streak?
- epiblast cell proliferation and movement caudally + medially, piling up in the midline
- name given to the cranial end of the primitive streak?
- Primitive knot, or HensenÂ’s node.
- what occurs during the first stages of gastrulation?
- epiblast cells ingress at primitive knot & primitive streak, and migrate rostrally & laterally
- name of the layer formed by migration of epiblast cells between endoderm & the epiblast?
- mesoderm
- what do some of the ingressing epiblast cells displace the hypoblast to form?
- single layered embryonic endoderm
- layer of overlying epiblast tissue on the surface of the embryo, facing the amniotic cavity called, once the mesoderm has formed?
- ectoderm
- How long does the primitive streak continue to form mesoderm?
- through the 3rd, 4th, & 5th weeks
- what happens to the primitive streak later in gastrulation?
- streak becomes smaller and more caudally situated as embryo grows. Usually disappears in 5th week.
- where is the streak situated at the time of its disappearance?
- in the area that will become the sacrococcygeal part of the trunk
- if primitive streak doesnÂ’t disappear, what can happen
- remnant causes sacrococcygeal teratoma
- what do the cells that are first to migrate through the primitive streak contribute to?
- tissues that contribute to rostral structures
- what do those cells that migrate through the streak later contribute to?
- progressively more caudal structures
- what happens to the cells that migrated rostrally first, while the primitive streak is still forming mesoderm and endoderm caudally?
- rostral tissues continue to grow, differentiate, and form organs
- what is the name given to the gradient in developmental activity?
- rostro-caudal gradient, because rostral structures develop first and are generally more developmentally well advanced than caudal structures.
- what do the cells which first ingress through HensonÂ’s node and migrate rostrally in the midline condense to form?
- rod-like structure called the notochord
- importance of the notochord?
- organizes subsequent embryonic development
- what does the ectoderm contribute to?
- nervous system, epidermis body surface tissues (epidermis, hair, nails), glands that connect by ducts to the body surface (sweat glands, sebaceous glands)
- process of neural tube developing into ectoderm?
- neurelation
- what is neural plate induction?
- notochord and adjacent paraxial mesoderm induce the overlying ectoderm to differentiate into a neural plate – a differentiated layer of ectoderm above the notochord
- what is the neural plate made up of?
- neuroectoderm
- what forms the neural folds?
- elevation of the edges of the neural plate, forming the neural fold
- name the cell types associated with the neural fold
- medial sides are neuroectoderm, non-neural ectoderm (surface) ectoderm is on lateral sides, mesoderm in core, neural crest cells at peak of crest
- what folllows development of the neural fold?
- neural folds contact, fuse at top, forming neural tube
- what does the neural tube develop into?
- brain and spinal cord
- what role does the non-neural ectoderm play after the neural tube has developed?
- comes together and seals over the neural folds, allows separation of the tube from the surface. this ectoderm becomes the skiin covering the brain & spinal cord
- what migrates next to the area between the neural tube and the ectoderm, and what does it form?
- mesoderm, which later forms the bones of the calvarium, covering the brain, and the vertebrae covering the spinal cord.
- what happens to the neural crest cells in this process?
- they migrate downwards, away from where the neural folds fused, and start to develop into the dorsal root ganglion
- initial contact between neural folds occurs where?
- site of the future cervical segment of spinal cord
- in which direction does the neural fold fusion process proceed?
- both cranially and caudally simultaneously
- which parts of the neural groove are last to close?
- the anterior and posterior neuropores
- where is the developing brain?
- anterior neuropore
- timing of closure of anterior and posterior neuropores?
- 23 days +/-
- what occurs if the neural folds fail to close?
- neurelation defect
- describe consequences if neural folds donÂ’t close
- failure of neural fold closure results in neural plate exposure on body surface: no skin covering the defect, therefore no space for the mesoderm to inhabit, so also so no bone development, no bony covering.
- most common neurulation defects?
- anencephaly when it occurs at the anteriormyeloschisis when it occurs posteriorly
- what happens to babies born with anencephaly?
- no skin over brain, no cranial vault, brain usually degenerates. usually die within hours of birth from infection
- what do the neural crest cells form?
- many structures related to the nervous system
- structures formed by the neural crest cells
- sensory neurons of dorsal root ganglia of spinal nerves; post-ganglionic autonomic neurons in sympathetic chain ganglia, visceral ganglia, etc... (Aurbachs and MeissnerÂ’s plexuses); endocrine cells in medulla of adrenal gland; schwann cells of peripheral nerves; melanocytes of skin; etc.
- endoderm form
- lining of the GI tract, and lining of ducts that open to tract, as well as their secretory cells (parenchyma) and glands
- what causes the embryo to fold during the 4th week of development?
- different rates in the growth of tissue
- what causes folding in the long axis?
- elongation of the neural tube and the notochord, producing the head and tail folds
- endoderm does what as the head and tail folds develop?
- endoderm rolls into the primitive foregut and hindgut
- primitive foregut forms?
- parts of the mouth, esophagus, stomach, and duodenum, as far as the opening of the common bile duct
- other imp. structures formed: prim. foregut outgrowth?
- respiratory airways, lungs, liver, gallbladder, pancreas
- what does the primitive hindgut form?
- large intestine from the distal part of the transverse colon to the anal canal and parts of the bladder and urethra
- when the tailfold rolls around, what is formed?
- it is flared – wider in elsewhere than rest of tube, so creeates bladder, rectum
- what causes the sides of the embryo to fold?
- enlargement of the somites
- endoderm does what during transverse folding?
- rolls into a primitive midgut
- what connects the primitive midgut to the remains of the yolk sac?
- vitelline duct (or yolk stalk)
- what does the primitive midgut form?
- small intestine from the opening of the common bile duct to the ileocecal junction, and the large intestine from the cecum to the distal part of the transverse colon
- mesoderm forms what in the embryo?
- most of the muscle and connective tissues
- subdivisions of mesoderm that run length of embryo?
- paraxial, lateral plate, and intermediate mesoderm
- what does the paraxial mesoderm do?
- blocks itself out into somites
- what forms the intraembrionic parietal coelum
- intercellular spaces in lateral plate – cavities coalescing
- what does the intermediate mesoderm form?
- kidneys and gonads
- what does the intraembryonic (visceral (splanchnic) mesoderm form
- connective tissues, vessels of digestive system and outgrowths
- where is the paraaxial mesoderm
- either side of the notochord
- in what order do somites form?
- craniocaudal sequence as paired blocks of cells in paraxial mesoderm
- what do the somites flank
- notochord and neural tube
- what do the somites develop into?
- vertebrae, intervertebral discs, ribs, skeletal muscles of the body wall, limbs, and contribute to body wall connective tissue
- where is the lateral plate mesoderm found?
- at periphery of embryo
- what forms in the lateral plate
- a cavity called the intraembryonic coelom
- what does this cavity divide the mesoderm into?
- somatic (parietal) and splanchnic (visceral) mesoderm
- what does the parietal mesoderm support?
- ectoderm
- what does the splanchnic mesoderm support?
- endoderm
- what does the somatic mesoderm contribute to?
- connective tissue, blood vessels, smooth muscle of body wall and limbs
- what does splanchnic mesoderm become?
- smooth muscle, blood vessels, connective tissue of GI tract and associated organs
- what does the intraembryonic coelom develop into?
- main body cavities: pleural, pericardial, and peritoneal
- where does the intermediate mesoderm lie?
- between the paraxial mesoderm and the lateral plate mesoderm
- what does the intermediate mesoderm contribute to?
- formation of urinary and reproductive systems
- when is most structure complete?
- by end of 8th week after fertilization
- embryonic period
- 0-8 weeks
- first two weeks
- transport & implantation
- 3 – 8 weeks
- morphogenesis, organogenesis
- Fetal Period
- 9 weeks to term
- during fetal period?
- growth and physiological maturation
- if adverse environment during 1-2 weeks: dev. response
- death or live, normal birth
- if adverse environment during gastrulation: dev. response
- multiple profound abnormalities
- if adverse environment 4 – 8 weeks: dev. response
- organ specific malformations
- if adverse environment fetal period: dev. response
- growth retardation and/or functional deficit(s)