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Skin Disorders

Terms

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Dermatitis =
inflammatory, itchy skin disorder due to allergy, chemical injury, or infection, usually type 4 hypersensitivity
Atopic dermatitis (eczema) =
itchy eruption on flexor surfaces (antecubital fossa, popliteal fossa), often associated with other allergic disorders like asthma and allergic rhinitis
Contact dermatitis =
type 4 hypersensitivity following contact with allergen like poison ivy/oak, nickel, latex, lesions occur at site of contact
Psoriasis =
epidermal hyperplasia with scaling (knees, elbows), see decreased stratum spinosum, bleeding when scratch off scales (Auspitz sign)
Dermatitis herpetiformis =
itchy papules and vesicles associated with celiac sprue
Lichen planus =
itchy purple polygonal papules, see lymphocytes at dermoepithelial junction
Erythema multiforme =
presents with multiple types of lesions like macules, papules, vesicles, and TARGET lesions, associated with infection, drugs, cancer, autoimmune disease
Stevens-Johnson syndrome =
type of erythema multiforme where have high FEVER, BULLA formation and necrosis, ULCERATION of skin, and high mortality rate
Seborrheic keratosis =
MULTIPLE pigmented squamous epithelium hyperplasia with keratin cysts, benign, old people
Actinic keratosis =
sun exposure, small rough red or brown papules, PREMALIGNANT to squamous cell CA! risk of cancer proportional to dysplasia
Keloid =
tumor of connective tissue, after skin trauma
Bullous pemphigoid =
autoimmune IgG Ab's against epithelial basement membrane, linear fluorescence, spares oral mucosa!
Pemphigus vulgaris =
potentially fatal autoimmune disorder IgG against epidermal cell surface (immunofluorescence throughout epidermis), involves oral mucosa
Squamous cell carcinoma of skin =
very common, sun exposure, arsenic exposure, hands & face, keratin pearls
Basal cell carcinoma =
sun exposure, pearly papules, palisading nuclei, locally invasive
Melanoma =
high risk mets, sun exposure and pale skin, risk of mets proportional to depth of tumor
Dysplastic nevus =
precursor to melanoma

Deck Info

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