Sem 1 Mini III Biochemistry Coagulation
Terms
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- ____ acts as a bridge between a specific glycoprotein on the surface of platelets (GPIb/IX) and collagen fibrils.
- vWF
- vWF binds to and stabilizes coagulation factor ____, and is required for normal survival of the factor in circulation.
- VIII
- The initial activation of platelets is induced by ____ binding to specific receptors on the surface of platelets, thereby initiating a signal transduction cascade.
- thrombin
- The factors involved in the intrinsic pathway are ____,____,____,____, and ___.
- VIII, XII, XII, IX, X
- The intrinsic pathway requires the proteins ____ and ____ secreted by the platelets along with Ca ions and phospholipids.
- prekalikrein, HK
- Initiation of the intrinsic pathway occurs when prekallikrein, high-molecular-weight kininogen, factor XI and factor XII are exposed to a _____ charged surface, and is termed the ____ phase.
- negatively, contact
- Conversion of prekallikrein to kallikrein, activates factor ____ to factor ___a.
- XII
- Factor XIIa activates _____ to _____ and factor ___ to factor ____a and leads to the release of bradykinin from high-molecular-weight kininogen.
- prekalkrien, kalikrein, XI, XI
- In the presence of Ca2+, factor XIa activates factor ___ to factor ____a.
- IX, IX
- Factors __, ___, ____, ____ contain vitamin K-dependent g-carboxyglutamate.
- prothrombin (II), VII, IX, and X
- The activation of factor ____ requires assemblage of the tenase complex on the surface of activated platelets.
- Xa
- The tenase complex consists of ___ and factors ___, ____, ____.
- Ca2+, factors VIIIa, IXa and X
- The role of factor ____ is to act as a receptor in the tenase complex.
- VIII
- The conversion of factor XIII to factor IIIa is activated by _____.
- thrombin
- In response to increased thrombin, factor VIIIa is cleaved by _____.
- thrombin
- Activated factor ____ is where the extrinsic and intrinsic pathways converge.
- Xa
- The extrinsic pathway is inititiated in the response to ____ factor.
- tissue
- The activation of factor VII occurs through the action of factor ____ or ___.
- Xa, thrombin
- ____ is a cofactor in the catalyzation of factor X by factor VIIa.
- TF
- Factor ____, a gla residue containing serine protease, cleaves factor X in a manner identical to that of factor ___ of the intrinsic pathway.
- VIIa, IXa
- Factor ___ of the intrinsic pathway can also be activated by factor VIIa and TF.
- IX
- persons with hereditary deficiencies in the components of the ____ phase of the intrinsic pathway do not exhibit clotting problems.
- contact
- Persons with hereditary deficiencies in the components of the contact phase of the intrinsic pathway do not exhibit clotting problems because of _____.
- factor VIIa and TF being able to activate factor IX
- ____ is a major extrinsic pathway inhibitor of the VIIa-TF complex.
- LACI
- LACI only binds to factor VIIa in the presence of factor ____.
- Xa
- The prothrombinase complex is formed from factors ____, ____, prothrombin and the platelet phospholipids and Ca ions.
- Xa, Va
- Thrombin combines with _____ present on endothelial cell surfaces forming a complex that converts protein C to protein Ca, which with cofactor protein S degrade factors ___ and ___.
- thrombomodulin, Va, VIIIa
- ____ is the most important thrombin inhibitor and also inactivates factors IXa, Xa, XIa and XIIa.
- antithrombrin III, IXa,Xa,XIa,XIIa
- a2-macroglobulin, heparin cofactor II and a1-antitrypsin are inhibiitors of _____.
- thrombin
- Active thrombin is a serine protease that _____ fibrinogen at four arg-gly bonds between the fibrinopeptide and the a and b portions of the protein.
- hydrolyses
- thrombin converts activates factor ___, a highly specific transglutaminase that introduces cross-links composed of covalent bonds between the amide nitrogen of ____ and e-amino group of _____ in the fibrin monomers.
- XIII, glutamines, lysines
- Any free circulating plasmin is rapidly inhibited by _____.
- a2-antiplasmin
- Plasminogen is activated by ____, ___ and ____.
- tPA, urokinase, streptokinase
- Hemophilia A is an X linked disorder associated with factor ___.
- VIII
- Hemophilia B is associated with defective factor ___.
- IX