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Terms Multiple Sclerosis


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Common in ages 20-40
More common in women
MS Demographics
Central Demyelatin Disease (CNS)
Etiology MS
A disease process that effects the nerve signal and how it is effectively moved down the axons in the SC
Nerve Conduction Principle
No specific lab test
Excessively tired
Flu-like symptoms
Dx of MS
1. Lower ex.
2. Upper ex.
3. Neurologic changes in thinking
Most typical progression of MS
Some myelination, no extensive/acute symptoms,
always goes back to baseline
Benign MS
No return to baseline after remitting
MOST common type
Relapsing/Remitting MS
Periods bet. exas & remiss become smaller then to primary
Secondary Chronic Progressive
Very rapid progression
Only 10-20% of Pts
Primary Progressive
Presence of plaque, CNS damage, possible optic nerve damage
Lesion and demyelinating process
The axons are intact but the myelin is effected.
Lesion and demyelinating process
saltatory conduction doesn't occur through the plaque and there is leakage of current
Lesion and demyelinating process
Heat effects nerve conduction - exacerbates symptoms
Axon shortens, Dendrite malformation, plaque around dendrite causes permanent conduction interruption
Axonal degeneration
conduction block
Acute demyelination
Development of this is protective in CNS - a physiologic response to and abnormal immuological response
Pins and needles in toes and fingers
Numbness in toes or fingers
S & S - MS
Speech and swallowing probs
Eye troubles
Slight memory problems
S & S - MS
Tremors in upper ext. particularly when picking up or writing
S & S - MS
Loss of balance, poor coordination, gait difficulties
S & S - MS
Bowel and bladder dysfunction
Sexual function problems
part or complete paralysis
S & S - MS
changes in brain - cognitive changes Optic Nerve - impaired acuity and color vision, sometimes only with heat
Clinical Picture by location MS
Brain stem - dysfunction of speech and swallowing, facial weakness, motor and sensory
Clinical Picture by location MS
Cerebellum discoordination in ambulation, vertigo
Clinical Picture by location MS
SC - heaviness and dragging of limbs, sensory, tone
Clinical Picture by location MS
Distal clumsiness, sexual dysfunction, bowel and bladder
Clinical Picture by location MS

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