Random ABX info
I did my best to use "group" (indicating 1 of the 9 different bacterial classes), and "drug" (indicating a specific agent on the Bug-Drug Grid). Be aware that the "written" questions are difficult to answer, and that also the randomly-generated matching and multiple choice questions sometimes (oftentimes) give you very obvious "wrong" answers - this is based on how I set up the data (as either a "term" or a "definition").
Terms
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- This group is often involved in mixed infections; often multiplies intracellularly; often lacks cell wall
- Atypicals
- Tigecycline covers all groups EXCEPT...
- Pseudomonas
- This drug has poor lung penetration due to binding to pulmonary surfactant
- Daptomycin
- This is the most resistant Gram pos group...
- Enterococci
- Azole antifungals inhibit these CYP isoforms...
- 2, 3
- Nitrofurantion/Fosfomycin cover these 2 groups...
- Enterococci, Enteric Gram Neg
- Only difference in coverage between amp/sulbactam and pip/tazo...
- Pseudomonas
- This drug is NOT recommended in CrCL < 50 ml/min
- Nitrofurantoin
- B-lactams do NOT cover this group...
- Atypicals
- This drug is considered an "azalide"
- Azithromycin
- These two classes bind to Ca+2 and are NOT recommended in children
- FQ, tetracyclines
- Macrolides do NOT cover this group...
- Enterococci
- Macrolides inhibit these two enzyme systems...
- 3A (BDZs, CCBs, Statins, Antiviral); PGP (Digoxin, Cyclosporine, Fexofenadine, CCBs)
- This drug may cause severe hepatotoxicity
- Telithromycin
- Aztreonam covers these 3 groups...
- Enteric Gram Neg, H-N-M, Pseudomonas
- Cephalosporins do NOT cover this group...
- Enterococci
- This drug's MOA is that it "binds to and disrupts cellular membranes causing bacterial cell lysis"
- Daptomycin
- Disulfiram rxn occurs with this ABX...
- Metronidazole
- Only carbapenem that doesn't cover Pseudomonas...
- Ertapenem
- Rifampin induces these enzyme systems...
- All of them!!!
- Many forms of this drug (e.g. X-estolate, X-stearate, X-ethyl succinate)
- Erythromycin
- Only macrolide to NOT cover H-N-M...
- Erythromycin
- This drug has weak MAOi activity
- Linezolid
- This group is often part of a "mixed infection"
- Anaerobes
- This ABX is the "King Inducer"...
- Rifampin
- This drug class is occasionally used (in low doses) in combo against Strep, Entero, Staph to "increase killing capacity
- AG
- QTc prolongation is a concern with this class
- Macrolides
- Cephamycins cover this important group...
- Anaerobes
- FQs inhibit this enzyme group...
- 1A2 - Warfarin, Theophylline/Caffeine
- Metronidazole covers this group...
- Anaerobes
- This class is primarily cleared renally (~100%)
- AG