Biochemistry Review 2
Terms
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Catabolsim is an essentially ______ process.
a. synthesis
b. exothermic
c. exothermic
d. isothermic - C
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T/F
Glycogenloysis is the cleavage of glucose-1-phosphate from the ends of glycogen molecules. - F
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Which of the following can enter the glycolysis pathway?
a. glucose
b. fructose
c. galactose
d. all of the following - D
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Which is the product of the first stage of glycolysis?
a. glucose-6-phosphate
b. pyruvate
c. glyceraldehyde-3-phosphate
d. lactate - C
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Under aerobic conditions in the body, pyruvate is converted to:
a. lactate
b. acetyl- CoA
c. ethanol
d. acetaldehyde - B
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One turn of the Krebs cycle produces ______ molecules of CO2.
a. 2
b. 3
c. 4
d. 5 - A
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The net yield of ATP from the complete catabolism of one molecule of glucose is:
a. 18
b. 24
c. 36
d. 42 - C
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The majority of ATP produced during the catabolism of glucose is formed during:
a. oxidative phosphorylation
b. glycolysis
c. the Kreb's cycle
d. glycogenolysis - A
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ASpproximately ___ percent of the energy available from glucose catabolism is trapped in the formation of ATP.
a. 20
b. 40
c. 60
d. 80 - B
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T/F
NADH is the coenzyme used in anabolism (synthesis). - F
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T/F
The protein complex which is responsible for respiration is imbedded in the inner mitochondrial membrane. - T
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T/F
The catabolism of fatty acids is called beta-oxidation. - T
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T/F
Ketone bodies are formed when the concentration of acteyl-CoA in the mitochondria is very high. - T
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T/F
In the cytoplasm acetyl-CoA is used in the synthesis of steroids. - T
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The activator/carrier molecule used in fatty acid biosynthesis is:
a. CoASH
b. ACP
c. FAD
d. NADH - B
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Which of the following is a ketone body?
a. acetyl CoA
b. acetone
c. acetaldehyde
d. malonyl-CoA - B
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The most important function of amino acids is for the synthesis of:
a. glucose
b. pyruvate for energy production
c. proteins
d. purines and pyrimidines - C
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Two key aminoacids in the catabolism of the amino group of the aminoacids are glutamate and _____.
a. phenylalanine
b. glycine
c. serine
d. asparate - D
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Oxidative deamination of the aminoacids produce:
a. urea
b. CO2 and HOH
c. ammonium ion
d. aspartate - C
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The direct "fuel" for the urea cycle is:
a. ammonium ion
b. glutamate
c. carbamoyl phosphate
d. pyruvate - C
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The production of glutamate from aspartate is called:
a. transamination
b. deamination
c. decarboxylation
d. aminogenesis - A
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T/F
Carbamoyl phosphate is produced by the reaction of CO2, ammonium ion and ATP. - T
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T/F
The second amino group of urea is derived from aspartate. - T
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T/F
The molecule which reacts with carbamoyl phosphate at the start of the urea cycle is oxaloacetate. - F
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Catabolism is an essentially ______ process.
a. anergonic
b. endergonic
c. exergonic
d. isergonic - C
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Direct phosphorylation of glucose by ATP leads to the formation of:
a. glucose-1-phosphate
b. glucose-6-phosphate
c. glucose-1,6-diphosphate
d. fructose-6-phosphate - B
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The product of glycogenolysis is:
a. glucose
b. glycogen
c. glucose-1-phosphate
d. glucose-6-phosphate - C
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Glycolysis occurs within the:
a. mitochondria
b. nucleus
c. ribosomes
d. cytoplasm - D
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Which of the following can not enter the glycolysis pathway?
a. glucose
b. fructose
c. galactose
d. glycogen - D
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Which coenzyme is used in most oxidation-reduction reactions of carbohydrate catabolism?
a. ATP/ADP
b. NAD+/NADH
c. NADP+/NADPH
d. CoASH - B
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Which is the production of the endergonic stage of glycolysis?
a. glucose-6-phosphate
b. pyruvate
c. glyceraldehyde-3-phosphate
d. lactate - C
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The net ATP output for glycolysis is ___ per glucose molecule.
a. 1
b. 2
c. 3
d. 4 - B
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Which of the following is the final product of glycolysis?
a. pyruvate
b. carbon dioxide and water
c. lactate
d. acetyl-CoA - A
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Which coenzyme must be reoxidized so that glycolysis can continue to produce energy?
a. NADH
b. NADP+
c. FADH2
d. NAD - A
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Under anaerobic conditions in the body, pyruvate is converted to:
a. lactate
b. acetyl-CoA
c. ethanol
d. acetaldehyde - A
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Under anaerobic conditions in a muscle cell, pyruvate is converted to:
a. ethanol
b. CO2 and HOH
c. acetyl-CoA
d. none of these - D
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T/F
The production of triose phosphates in the first stage of glycolysis is an endothermic sequence of reactions. - T
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The oxidative (aerobic) reactions of metabolism occur in the:
a. cytoplasm
b. mitochondria
c. nucleus
d. ribosomes - B
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The direct precurser for the citric acid cycle is:
a. glucose
b. glycogen
c. fatty acids
d. acetyl-CoA - D
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Glyceraldehyde-3-phosphate and dihyroxyacetonephosphate are:
a. triose
b. functional isomers
c. monosaccharides
d. all of the above - D
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The products of the tricarboxylic acid cycle are CO2 and:
a. 3NADPHs, 1FAD, and 1ATP
b. NAD+
c. NADPH
d. 3NADH, 1FADH, and 1GTP - D
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T/F
Gluconeogenesis is the porduction of glucose from non-carbohydrate sources. - T
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T/F
The electron transport system (ETS) of respiratory chain is found dispersed in the mitochondrial matrix. - F
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What metal ions are present in the cytochromes of the ETS aid in the passage of electrons down the chain?
a. Cr+++ and Ca++
b. Fe++ and Fe+++
c. Zn and Zn++
d. Na+ and Mg++ - B
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The final electron acceptor during resiration is:
a. NAD
b. NADH2
c. FAD
d. O2 - D
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The formation of ATP in the ETS is called:
a. reductive phosphorylation
b. substrate phosphorylation
c. oxidative phosphorylation
d. substrate oxidation - C
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T/F
It is possible to oxidize the hydrogen atoms of acetyl-SCoA without having oxidative phosphorylation occur. - T
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T/F
Oxidative phosphorylation and electron transport are coupled in the ETS. - T
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T/F
Glycogenolysis directly leads to the formation of glucose-6-phosphate which undergoes glycolysis. - F
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An important product of pentose phosphate pathway (shunt) is:
a. NADH
b. NADPH
c. FADH2
d. FPH2 - B
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Another important product of the pentose shunt is:
a. ribose-5-phosphate
b. fructose-1,6-diphosphate
c. galactose-1-phosphate
d. phosphoenolpyruvate (PEP) - A
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T/F
NADPH is the coenzyme used in anabolic reations(synthesis). - T
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T/F
The protein complex which is resonsible for respiration is dispersed in the mitochondrial matrix. - F
- Before fats and oils can be metabolized, fatty acids must be relesed from triglycerides with the aid of a triglyceride lipase.
- T
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T/F
The anabolism of fatty acids is called beta-oxidation. - F
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The activator/carrier molecule used in fatty acid catabolism is:
a. coenzyme-A, CoASH
b. acyl carrier protein (ACP), fatty acid synthestase
c. NAD +
d. ATP - A
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Complete beta-oxidation of a 12-carbon fatty acid produces ___ molecules of acetyl-CoA.
a. 2
b. 4
c. 6
d. 12 - C
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T/F
Beta-oxidation occurs in the cytoplasm of a cell. - F
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T/F
Fatty acid synthesis is the complete reverse of beta-oxidation. - F
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The protein which is responsible for the transport of fatty acids through the inner mitochondrial membrane into the matrix is:
a. CoASH
b. ACP
c. carnitine
d. albumin - C
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T/F
The synthesis of a 12 carbon fatty acid is achieved bu the sequential condensation of 6 acetyl CoA molecules. - F
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Which coenzyme is the reducing agent used in fatty acid biosynthesis?
a. NAD+
b. NADH
c. NADPH
d. FADH2 - C
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T/F
The key intermediate in fatty acid synthesis is the free three carbon diacid malonate. - F
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T/F
Ketone bodies are formed when the concentration of acetyl-CoA in the cytoplasm is very high. - F
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T/F
In the cytoplasm acetyl-CoA is used in the synthesis of non-saponifiable lipids. - T
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The activator/carrier molecule used in fatty acid oxidations is:
a. CoASH
b. ACO
c. FAD+
d. NADH - A
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Which of the following is a ketone body?
a. acetyl-CoA
b. acetone
c. malonate
d. malonyl-CoA - B
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The most important function of aminoacids is for the synthesis of:
a. glucose
b. pyruvate for energy production
c. proteins
d. purines and pyrimidines - C
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The key aminoacids in the catabolism of the amino group of aminoacids are glutamate and ______.
a. phenylalanine
b. glycine
c. serine
d. aspartate - D
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Oxidative deamination of aminoacids directly produces:
a. urea
b. glutamate
c. carbamoyl phosphate
d. pyruvate - C
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the production of glutamate from alpha-ketoglutarate is called:
a. transamination
b. deamination
c. decarboxylation
d. aminogenesis - A
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The second amino group of urea is derived from:
a. glucose
b. glutamate
c. aspartate
d. acetate - C