Anti cancer drugs
Terms
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- Charcteristics of cell cycle specific drugs
- Don't act in G0 phase, used in a schedule dependent way, best killing is seen if drug is given in repeated small fractions, work best of tumors with high GF
- Which drugs are CCS?
- Antimetabolites, Vinka alkaloids, padaphyllotoxins (G2/s), Bleomycin (G2)
- Characteristics of CCNS drugs?
- cytotoxic effect at any time in cell cycle, dose dependent effect
- Which drugs are CCNS?
- alkylating agents, platinums, DNA breakers, antibiotics (except bleomycin)
- Log-kill hypothesis
- cancer drugs kill a fixed proportion of the cancer cells not a fixed number
- 4 classes of anti cancer drugs
- DNA alkylatinf agents, antimetabolites, drugs that act on mitotic spindle, antibioticsm hormonal agents
- this class of drugs does concentration dependent killing
- CCNS
- what is growth fraction/
- proportion of tumor cells that are actively dividing
- vinca alkaloids act in what phase?
- M phase
- Podophyllotoxins act in what phase?
- early G2 or s phase