Mechanisms of Disease 2
Terms
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- Most Common form of arthritis
- OA
-
As __ progresses, crystals of calcium phosphate are shed into the joint fluid and are commonly found in
severe __ - OA
-
PATHOLOGY OA
Gross Level -
- first see cartilage irregularities and splitting.
- next see ulceration of cartilage and frank cartilage loss
- next, bone-on-bone contact then eburnation (polished bone) -
PATHOLOGY OA
Microscopic Level - - see fibrillation of cartilage
- Inflamation in OA
- Inflammation is not a significant component of OA. it is not considered an inflammatory condition or disease.
-
OA PATHOLOGY
biochemically -
-decreased glycosaminoglycan content of cartilage including
less keratan
less hyaluronic acid
less chondroitin sulfate - Though __ parallels age, it is not considered a NL feature of aging
- OA
- Develops routinely in people whose occupations cause repetitive stress/trauma/impact to one or more joints
- OA
- Obesity increases risk for __, especially in the knees
- OA
- Most common joints affected in OA
-
lumbosacral spine
hips
knees
feet
but also cervical spine and PIP and DIP joints - MMP
-
Matrix Metalloproteinase
increased in OA
play significant
role in degradation of extracellular matrix of cartilage - OA is primarily a disease of the _____ _____ of joints.
- hyaline cartilage
- Pathogenic Theory of OA
-
mechanical stress which > change in chondrocyte metabolism >
proteolytic enzyme production (MMPs) >
disruption of cartilage matrix -
As OA progresses, crystals of _______ _______ are shed into the joint fluid and are commonly found in
severe OA - calcium phosphate
- Morning stiffness < 30 min is a common symptom of _____
- OA
- Gelling
- stiffness after short periods of rest
- Possible reasons for OA associated pain
-
periostitis
subchondral microfractures
osteophytes (synovial nerve ending irritation)
muscle spasm
synovial inflammation (by chem junk)