2 Bio Chem Krebs
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- where are they glycolytic enzymes located?
- in cytosol
- what activates the 3 irreversible steps of kreb cycle and pDH?
- ^^^ ADP and NAD
- what forms G6P--> glucose
- G6Phophotase in gluconeogenisis
- where are Reduce coenzymes formed in the krebs cycle?
- Isocitrate DH, Alpha ketogluterate DH complex, Succenate DH and MALAT DH (All the DH reactions reduced coenzmes)
- What to things can form PEP?
- Pyruvate and Oxaloacetate
- what is glyconeogenisis?
- synthesis of glucose in LIVER (sometime kidne)
- What forms F16BP--> F6p?
- F16BP phosphotase in gluconeogensis
- what are the four coenzymes
- TPP (1st) then NAD, FAD, CoASH
- what does pyruvate DH essentially do
- convert pyruvate to acetyl coA that enters kreb ccle
- what enzyme is responsible for making oxaloacetate from pyruvate?
- pyruvate carbodylase-biotin
- how many catalytic rxn for krebs?
- 8 rxn
- where do you get NADH from gylcolysis?
- glyceraldehyde 3 phosphate DH rxn
- what does the pyruvate DH complex consist of?
- 5 enzymes and 4 coenzymes
- What are the products from pyruvate DH complex?
- NADH and Acetyle COa
- fxn of biotin
- carries co2
- what DEactivates the 3 irreversible steps of kreb cycle and pDH?
- ^^^ ATP and NADH
- whatis the mechanism of gluconeogensisis?
- reverse of glycoloysis EXCEPT irreversible steps
- what is located in the mitochondria?
- pyruvate DH and kreb cycle enzymes
- where does glyconeogensis occur?
- in LIVER- sometimes kidneys
- where is the pyruvate DH and kreb cycle enzymes located?
- mitochondria
- what are the three irreversibe steps of krebs cycle?
- citrate syntase, isocitrate DH, 2 ketogluterate DH
- what forms the only reduce FADH in the krebs cycle?
- Succinate DH
- What is located in the cytosol of the cell?
- glycolytic enzmes
- why is gluconeogensis important
- keeps glucose conc. constant- if there is no more glycogen (that is broken down to make sugar) then makes glucose
- Purpose of krebs
- convert aetyl coa to Co2 and H2O
- what formes the tetrehedral intermediate btw pyruvate and acetyl coa?
- PDC-TPP (tpp attached and kickes out CO2)
- what accounts for the NADH formed outside both glycoloysis and krebs?
- Pyruvate DH complex rxn
- what makes PEP from oxaloacetate?
- PEP carboxykinase and GTP-->GDP
- what are all the places where regulation can occur (starting with glyc?)
- HX/GK PFK, PK, Pyruvate DH, Citrate syntase, Isocirate DH and 2 Ketogluterage DH
- what are the rxns that occur btw the tethedral intermediate and formation of Acetyl Coa?
- FAD<-> FADH, NADH is formed and CoaSH goes into