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med chem chemotherapy of viral infections part 1

Terms

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Single stranded RNA(+) strand viruses
genome serves as mRNA
rhinovirus (cold)
enterovirus (polio)
togavirus (rubella/german measles)
Single stranded RNA (-) strand
viruses
Genome is the template from which mRNA is transcribed
Orthomyxovirus (influenza)
rhabdovirus (rabies)
morbillivirus (measles)
paramyxovirus (mumps)
RSV (bronchiolitis & pneumonia)
Double stranded RNA (+/-) strands
Reovirus (resp and GI sxs)
Coronavirus (SARS)
Retroviruses
HIV
Single stranded DNA viruses
Parvovirus (gastroenteritis, canine distemper)

Bacteriophage (vectors,biotech)
Double stranded DNA viruses
HSV1
HSV2
Herpes zoster
CMV
Papovavirus (genitral warts, plantar warts
Poxvirus (small pox)
Stages of the viral life cycle
A. DNA viruses
Step1
Attachment (virion-virulent viral particle)
step2
penetration (pinocytotic mechanism)
step3
uncoating (ion transport channels) and transfer of viral DNA to nucleus
step4
early transcription into viral mRNA
step5
early translation of viral mRNA into enzymes for viral DNA synthesis
step6
synthesis of viral DNA and late transcription of viral mRNA
step7
late translation of mRNA into viral structural protiens (interferons alpah, beta, gamma)
step8
assembly of virus particles in nucleus (genome encased by new capsid proteins)
step9
budding atom nucleus and release of virions (also by lysis)
Retrovirus stages
binding-> uncoating -> reverse transcriptase + RNASE (genomic RNA -> double stranded DNA) ->integration into cell nucleus->transcription to proviral RNA ->viral mRNA undergoes translation to form viral proteins or genomic RNA assembles into cell membrane -> release required by HIV protease

Deck Info

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