neuroendocrine system
Terms
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- causes 80% of primary hyperparathyroidism
- adenoma of parathyroid
- encapsulated proliferation of chief cells
- adenoma of parathyroid
- most common cause of secondary hyperparathyroidism
- chronic renal disease leading to hypocalcemic stimulation of PTH secretion
- cause of death due to carcinoma of parathyroid
- hyprecalcemia, not widespread organ replacement
- causes of hypoadrenalism
-
primary chronic insufficiency (addison's disease)
primary acute insufficiency (crisis in chronix sit) - causes of hyperadrenalizm
-
hyperaldosteronism (conns syndrome)
hypercortisolism
hypersecretion of sex steroid - most common cause of adrenocortical hyperfunction
-
hypercortisolism
pituitary cushings syndrome, adrenal cushings sydrome, paraneoplastic - prognosis of cortical carcinoma of adrenal gland
- poor
- medullary adrenal pathology
-
pheochromocytoma
neuroblastoma - secretes epi and NE causing HTN
- pheochromocytoma
- only absolute criterion for malignancy in pheochromocytoma or gastrinoma
- presance of metastasis
- most common tumors in infancy and childhood
- neuroblastoma
- increased urinary homovanillic acid, vanillylmandelic acid, dopamine, metanephrine
- neuroblastoma
- arises from chief cells of paraganglia
- paraganglioma
- carotid and aorticopulmonary paraganglioma are termed
- chemodectomas
- most common type of islet cell tumor
-
beta cel insulin
insulinoma - presents with multiple peptic ulcers, high gastric acid secretion and plasma gastrin levels
- zollinger ellison syndrome
- MEN-1
- gene that predisposes patient to multiple endocrine neuplasia
- MENI
- neoplasms of parathyroid glands, adrenal cortex, pituitary, pancreas
- MENIIa
- pheochromo, medullary carc of thiroid, parathyrroid hyperplasia
- sipple yndrome
- MENIIa
- MENIIb
- same as IIa, no parathyroid abn, but with mucocutaneous neuromas