Shelf: Block 4: Chemo Superstar
Terms
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- Melphalan
- Nitrogen mustard~ alkylating agent
- Chlorambucil
- Nitrogen mustard~ alkylating agent
- Cyclophosphamide
- Nitrogen mustard~ alkylating agent
- Infosfamide
-
Nitrogen mustard~ alkylating agent
Testicular cancer - Thiotepa
- Ethylenimine ~ alkylating agent
- Busulfan
- Alkylsulfonate ~ alkylating agent
- BCNU (carmustine)
-
Nitrosourea ~ alkylating agent
Malignant glioma - CCNU (lomustine)
- Nitrosourea ~ alkylating agent
- Methyl CCNU (semustine)
- Nitrosourea ~ alkylating agent
- Streptozocin
-
Methylnitrosourea ~ alkylating agent
Pancreatic cancer - Dacarbazine
- Triazene ~ alkylating agent
- Temozolamide
-
Triazene ~ alkylating agent
Anaplastic astrocytoma - Cisplatin
-
~ alkylating agent
Testicular cancer - Procarbazine
-
~ alkylating agent (DNA, RNA, and protein)
Hodgkin's lymphoma - Vincristine
- Natural product
- Vinblastine
- Natural product
- Vinorelbine
- Synthetic derivative of vinblastine
- Paclitaxel (Taxol)
-
Taxane ~natural product
Breast and ovarian cancer
Prevention of restenosis - Abraxane
- Protein bound nonparticle formulation of Taxol
- Dacetaxel (Taxotere)
- Synthetic analogue of Taxol
- VP-16 (etoposide)
-
Epipdophyllotoxin~ natural product
Hodgkin's dz, Diffuse histiocytic lymphoma, and small cell of the lung - VP-26 (teniposide)
-
Epipdophyllotoxin~ natural product
Hodgkin's dz, Diffuse histiocytic lymphoma, and small cell of the lung - Irinotecan
-
Camptothecin derivative~ natural product
Lung and metstatic colon cancer - Topotecan
- Camptothecin derivative~ natural product
- Dactinomycin
-
Antibiotic
Can cause radiation sensitivity - Daunorubicin
-
Anthracycline~ antibiotic
Cardiotoxicity - Doxorubicin
-
Anthracycline~ antibiotic
Cardiotoxicity - Epirubicin
-
Anthracycline~ antibiotic
Cardiotoxicity - Mitoxantrone
-
Anthracycline~ antibiotic
Cardiotoxicity - Dexrazoxane
-
Fe chelator
Given to reduce cardiotoxicity from Anthracyclines - Bleomycin
-
Antibiotic
DNA binding and Fe binding regions - Methotrexate
-
Antimetabolite- folic acid analogue
Affects S phase of DNA cycle - Leucovorin
- Abborts MTX toxicity
- Pemetrexed
- Antimetabolite- Folate antatgonist
- 5-Fluorouracil
- Antimetabolite- Pyrimidine Analogue
- Floxuridine
- Antimetabolite- Pyrimidine Analogue
- Capecitabine
-
Antimetabolite- Pyrimidine Analogue
Metastatic breast and colon cancer - 3-deazauridine
- Antimetabolite- Uracil analogue
- 6-azauridine
- Antimetabolite- Uracil analogue
- Cytosine arabinoside
-
Antimetabolite- cytidine analogue
Hematologic malignancies - Gemcitabine
-
Antimetabolite- cytidine analogue
Advanced breast cancer, non small cell lung cancer, pancreatic carcinoma, ovarian cancer - 5-azacytidine
-
Antimetabolite- pyrimidine analogue (cytidine)
Myelodysplastic syndrome - 6-mercaptopurine
- Antimetabolite- purine analogue
- 6-thioguanine
- Antimetabolite- purine analogue
- Pentostatin
-
Antimetabolite- purine analogue
Hairy cell leukemia - Clofarabine
-
Deoxyadenosine analogue
(-) DNA poly - Hydroxyurea
- Antimetabolite
- Asparaginase
- Enzyme
- Imatinib mesylate (Gleevec)
-
Biological response modifier
CML and GI stromal tumors - Erlotinib
-
BRM
(-) EGF receptor tyrosine kinase - Gefitinib
-
BRM
(-) EGF receptor tyrosine kinase - Trastuzumab (herceptin)
-
BRM
Her2 (+) breast cancer - Cetuximab
- BRM
- Bevacizumab
-
BRM
VEGF receptor - Rituximab
-
BRM
Non-Hodgkin's lymphoma
Can reactivate HBV - Ibritumomab tiuxetan (Zevalin)
-
BRM
Linked to yttrium-90 and indium-111 - Tositumomab
-
BRM
Linked to iodine-131 - Gemtuzumab ozogamicin (Mylotarg)
-
BRM
Acts at Myeloid cell surface antigen CD33 - Calicheamicin
- DNA cleaving Ab conjugated to Mylotarg
- Levamisole
- BRM
- IL-2 (Aldesleukin)
- BRM
- Interferon alpha
-
BRM
Multiple Myeloma
Kaposi's sarcoma - Thalidomide
-
BRM
Multiple Myeloma - All-trans-retinoic acid
-
BRM
AML - Aresenic trioxide
-
BRM
Second line for AML - Bexarotene
-
BRM
Cutaneous T cell lymphoma - Denileukin difitox
- BRM
- Samarium SM 153 lexidronam
-
BRM
Metastatic bone lesions - Alemtuzumab
-
BRM
CLL - Bortezomib
-
BRM
Multiple myeloma - Celecoxib
-
BRM- COX 2 inhibitor
Prevention of cancer in familial adenomatous polyposis - Pamidronate
-
Bisphosphonate
Hypercalcemia, osteolytic bone lesions in MM, metastatic breast cancer, bone metastases from solid tumors - Etidronate
-
Bisphosphonate
Hypercalcemia, osteolytic bone lesions in MM, metastatic breast cancer, bone metastases from solid tumors - Zoledronate
-
Bisphosphonate
Hypercalcemia, osteolytic bone lesions in MM, metastatic breast cancer, bone metastases from solid tumors - bacillus Calmette-Guerin (BCG)
-
BRM
Bladder cancer - Palifermin
-
BRM
Treats chemo induced mucositis - Tamoxifen
-
Antiestrogen
Breast cancer in postmenopausal women - Raloxifene
- Selective estrogen receptor modulator (SERM)
- Fulvestrant (Faslodex)
- True estrogen receptor antagonist
- Aminoglutethimide
-
Aromatase inhibitor
2nd line for metstatic breast cancer - Anastrozole
-
Nonsteroidal Aromatase inhibitor
Alternate 1st line therapy for breast cancer - Letrozole
- Nonsteroidal Aromatase inhibitor
- Megestrol
-
Progesterone agonist
Advanced breast cancer
Anorexia/cachaexia
Prostate cancer - Medroxyprogesterone
-
Progesterone agonist
Advanced breast cancer
Anorexia/cachaexia
Prostate cancer - Leuprolide
-
Gonadotropin-releasing hormone agonist
Prostate cancer
Metstatic breast cancer in Premenopausal women - Goserelin
-
Gonadotropin-releasing hormone agonist
Prostate cancer
Metstatic breast cancer in Premenopausal women - Flutamide
-
Nonsteroidal antiandrogen
Metastatic prostate cancer - Bicalutamide
-
Nonsteroidal antiandrogen
Prostate cancer - Dietheylstilbesterol
- Old drug for prostate cancer not used anymore
- Ketoconazole
-
Adrenal enzyme synthesis inhibitor
2nd line for prostate cancer