Skin Disorders
Terms
undefined, object
copy deck
- Dermatitis =
- inflammatory, itchy skin disorder due to allergy, chemical injury, or infection, usually type 4 hypersensitivity
- Atopic dermatitis (eczema) =
- itchy eruption on flexor surfaces (antecubital fossa, popliteal fossa), often associated with other allergic disorders like asthma and allergic rhinitis
- Contact dermatitis =
- type 4 hypersensitivity following contact with allergen like poison ivy/oak, nickel, latex, lesions occur at site of contact
- Psoriasis =
- epidermal hyperplasia with scaling (knees, elbows), see decreased stratum spinosum, bleeding when scratch off scales (Auspitz sign)
- Dermatitis herpetiformis =
- itchy papules and vesicles associated with celiac sprue
- Lichen planus =
- itchy purple polygonal papules, see lymphocytes at dermoepithelial junction
- Erythema multiforme =
- presents with multiple types of lesions like macules, papules, vesicles, and TARGET lesions, associated with infection, drugs, cancer, autoimmune disease
- Stevens-Johnson syndrome =
- type of erythema multiforme where have high FEVER, BULLA formation and necrosis, ULCERATION of skin, and high mortality rate
- Seborrheic keratosis =
- MULTIPLE pigmented squamous epithelium hyperplasia with keratin cysts, benign, old people
- Actinic keratosis =
- sun exposure, small rough red or brown papules, PREMALIGNANT to squamous cell CA! risk of cancer proportional to dysplasia
- Keloid =
- tumor of connective tissue, after skin trauma
- Bullous pemphigoid =
- autoimmune IgG Ab's against epithelial basement membrane, linear fluorescence, spares oral mucosa!
- Pemphigus vulgaris =
- potentially fatal autoimmune disorder IgG against epidermal cell surface (immunofluorescence throughout epidermis), involves oral mucosa
- Squamous cell carcinoma of skin =
- very common, sun exposure, arsenic exposure, hands & face, keratin pearls
- Basal cell carcinoma =
- sun exposure, pearly papules, palisading nuclei, locally invasive
- Melanoma =
- high risk mets, sun exposure and pale skin, risk of mets proportional to depth of tumor
- Dysplastic nevus =
- precursor to melanoma