heme
Terms
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Hemophilia A
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F VIII deficiency
x-linked reccesive
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CD markers in Hodgkin's
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CD15, CD30
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follicular lymphoma
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t(14,18) bcl-2 expression (anti-apoptosis gene)
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burkitt's lymphoma
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t(8,14) c-myc moves from 8 to 14
-
ras
L-myc
N-myc
c-myc
ret
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colon
lung
neuroblastoma
burkitt's
MEN IIa, IIb
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rescue for methotrexate toxicity
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leukovirin (folinic acid)
- filgrastim
- G-CSF
- raloxifene
-
SERM (like tamoxifen)
used to tx osteoporosis
no increased risk of endometrial cancer
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antidote for heparin
antidote for Vit K
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protamine sulfate (positive charge binds heparin)
IV vit k and FFP
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heparin vs. warfarin in pregnancy
- heparin doesn't cross the placenta
- thrombolytics
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streptokinase, urokinase, tPA(alteplase), APSAC (anistreplase)
reverse w/ aminocaproic acid
- CD4
-
t-cell marker
- macrophages are activated by?
- gamma-interferon
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serum vs. plasma
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plasma has all the clotting factors, serum doesn't
- effects of kallikrein
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activate plasminogen (create plasmin)
activate HMWK (create bradykinin)
*kallikrein is activated by the clotting pathway and then serves to inhibit the pathway
-
what activates kallikrein
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factor XIIa
(pre-kallikrein-->kallikrein)
- effect of plasminogen on complement
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convert C3 to C3a
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classical complement pathway
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Abs (IgG and IgM) bind pathogen
C2 and C4 are unique
classic convertase is C4b/C2a
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alternative complement pathway
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Activated by microbial surfaces (including endotoxin)
factor B is unique
alternative convertase is C3b/Bb
- deficiency of C1 esterase inhibitor
-
autosomal dom hereditary angioedema
- low levels of C2
- sepsis or lupus rxn
-
deficiency of C3
-
susceptible to pyogenic infections
- deficiency of C6-C8
-
neisseria infection
- deficiency of decay accelerating factor
- PNH
- anaphylaxis mediated by? (complement)
-
C3a and C5a
-
neutrophil chemotaxis by? (complement)
- C5a
- opsinization by? (complement)
- C3b
-
false positive VRLDL
- lupus anticoagulant
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Hemophilia B
-
F IX deficiency
- CD1
- histeocyte (more generally, APCs)
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CML genetics
-
t(9,22) bcr-abl
low leukocyte alk phos! (vs leukomoid rxn)
- which two helminth infections don't have eosinophilia
- pinworm, adult ascariasis
- monocytosis
- chronic inflammation/malignancy
- acute promyelocytic leukemia
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t(15,17)
tx w/ retinoic acid