Beta-Blockers
Terms
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- Nadolol
-
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 1st - Penbutolol
-
MSA: 0
Lipid sol: High
ISA: +
Generation: 1st - Pindolol
-
MSA: +
Lipid sol: Low
ISA: +++
Generation: 1st - Propranolol
-
MSA: ++
Lipid sol: High
ISA: 0
Generation: 1st - Timolol
-
MSA: 0
Lipid sol: High
ISA: 0
Generation: 1st - Acebutolol
-
MSA: +
Lipid sol: Low
ISA: +
Generation: 2nd - Atenolol
-
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 2nd - Bisoprolol
-
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 2nd - Esmolol
-
MSA: 0
Lipid sol: Low
ISA: 0
Generation: 2nd - Metoprolol
-
MSA: + (high doses)
Lipid sol: Moderate
ISA: 0
Generation: 2nd - Cartelol
-
MSA: 0
Lipid sol: Low
ISA: ++
Other actions: (up) NO; B2 agonist
Generation: 3rd - Carvedilol
-
MSA: ++
Lipid sol: Moderate
ISA: 0
Other actions: a1 blockade; antioxidant; antiproliferative
Generation: 3rd - Labetalol
-
MSA: +
Lipid sol: Low
ISA: +++
Other actions: a1 blockade; B2 agonist
Generation: 3rd - Betaxolol
-
MSA: +
Lipid sol: Moderate
ISA: 0
Other actions: vasodilation; Ca++ entry blocker
Generation: 3rd - Beta-Blockers: Clinical Indications
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-Hypertension
-Glaucoma
-Migraine prophylaxis
-Hyperthyroidism
-Angina pectoris
-Acute MI
-Supraventricular arrhythmias
-Acute panic attacks
-Benign essential tremor
-Congestive heart failure - Beta-Blockers: MOA
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-decrease CO (B1)
-decrease Ang II (B1)
-decrease NE release (B2)
-decrease SNS centrally
*Altered baro-reflex - Beta-Blockers: Adverse Effects
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-Bronchoconstriction
-Cardio-depressive actions
-Disturbed glucose metabolism
-Impaired peripheral circulation
-Sudden withdrawal syndrome
-CNS effects (depression, nightmares, fatigue)
-Elevated triglycerides - Beta-Blockers: Drug Interactions
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-Verapamil (CCB)
-Diltiazem (CCB)
-Clonidine (a2 blockers)